The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review

International Journal of Molecular Sciences
Miroslav PetrAgnieszka Maciejewska-Skrendo

Abstract

The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators' polymorphisms can predict the training response to specific training stimuli. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words. All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO₂peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO₂peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/...Continue Reading

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Citations

Apr 16, 2019·Journal of Strength and Conditioning Research·Petr StastnyPawel Cięszczyk
Oct 1, 2020·International Journal of Sport Nutrition and Exercise Metabolism·Giuseppe Delli PaoliPieter de Lange
Jul 31, 2019·Genes·Isabel Espinosa-SalinasAna Ramirez de Molina
Oct 9, 2020·PPAR Research·Runzhi HuangZongqiang Huang
Jul 22, 2020·International Journal of Sports Medicine·Javier Alvarez-RomeroDanielle Hiam
Mar 26, 2021·Frontiers in Genetics·Manuel CorpasEdmund Lehmann
May 15, 2021·Journal of Biomedical Science·Camilla J WilliamsJeff S Coombes
Aug 28, 2021·International Journal of Molecular Sciences·Mounia Tahri-JouteyNorbert Latruffe

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