PMID: 7581218Jul 28, 1995Paper

The role of pharmacists in the recruitment of a cohort for postmarketing surveillance. A case study of acitretin in The Netherlands

Pharmacy World & Science : PWS
M C SturkenboomH Wesseling

Abstract

In October 1990, a recall procedure was issued regarding the drug acitretin. The recommended post-therapy contraception period after acitretin therapy was extended from 2 months to 2 years. For a postmarketing surveillance study, we recruited a cohort from the source population of women aged 15-45 years who were exposed to acitretin. Recruitment occurred through dermatologists, and pharmacists plus dispensing general practitioners. We describe the speed of and the response to the recruitment procedures, and the representativeness of the recruited cohort. We also studied whether the individuals who gave informed consent would have preferred to be recruited by either dermatologists or pharmacists, and whether the information obtained from pharmacists and dispensing general practitioners was valid. This study revealed that pharmacists and dispensing general practitioners (drug dispensers) recruited their subjects rapidly, with no or little selection; they attained a 42% response. Dermatologists recruited their subjects slowly and selectively; they attained a 24% response. The majority of women (60%) recruited by dermatologists would have given their informed consent if they would have been recruited by their pharmacists. Drug disp...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·B H StrickerP A de Smet
May 1, 1992·American Journal of Epidemiology·S WacholderJ S Mandel
Sep 1, 1991·British Journal of Industrial Medicine·P F Gannon, P S Burge
Jan 1, 1982·Journal of Chronic Diseases·E K Borden, J G Lee
Jan 1, 1993·European Journal of Clinical Pharmacology·L T de Jong-van den BergH Wesseling

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