The role of phenotype on ventilation and exercise capacity in patients affected by COPD: a retrospective study

Multidisciplinary Respiratory Medicine
Rocco F RinaldoFabiano Di Marco

Abstract

The idea of phenotype in chronic obstructive pulmonary disease (COPD) has evolved in the last decades, and the importance of peculiar treatment strategies has now been acknowledged. Although dyspnea and exercise limitation are hallmarks of COPD, this aspect has never been fully explored in literature in terms of disease phenotype. The aim of the present study was to explore the relevance of clinical COPD phenotypes on exercise ventilation and maximal capacity. In this observational cohort retrospective study we analyzed the data of 50 COPD patients who underwent cardiopulmonary exercise test, categorized as emphysematous (n=29), and non-emphysematous (n=21) according to a previously validated model. We found a significant difference in terms of VE/VCO2 slope (median values 32.4 vs 28.0, p=0.015) and VE/VCO2 ratio at nadir (median values 37 vs. 33, p=0.004), which resulted higher in emphysematous patients, who also presented lower PETCO2 values (median values 32.6 vs 35.6, p=0.008). In a subgroup of 31 tests which met the maximality criteria, emphysematous patients presented a significantly lower work rate at peak (median value 51 vs 72% predicted, p=0.016), and showed a lower peak oxygen consumption, although at the limit of si...Continue Reading

References

Nov 27, 2002·American Journal of Respiratory and Critical Care Medicine·Xing-Guo SunKarlman Wasserman
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Oct 6, 2005·The European Respiratory Journal·N MacintyreJ Wanger
Nov 3, 2005·The European Respiratory Journal·R PellegrinoJ Wanger
Mar 5, 2008·American Journal of Respiratory and Critical Care Medicine·Peter Calverley
Jun 4, 2008·European Journal of Applied Physiology·Maurizio BussottiPiergiuseppe Agostoni
Jun 23, 2009·American Journal of Respiratory and Critical Care Medicine·Francisco Garcia-RioRodolfo Alvarez-Sala
Jun 5, 2010·American Journal of Respiratory and Critical Care Medicine·MeiLan K HanFernando J Martinez
Mar 17, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Eduardo Márquez-MartínFrancisco Ortega Ruiz
Aug 16, 2011·Respiratory Physiology & Neurobiology·Patrizia PaolettiPaolo Palange
Dec 21, 2011·The European Respiratory Journal·Jordan A GuenetteDenis E O'Donnell
Nov 2, 2012·The Open Respiratory Medicine Journal·Li-Fei ChenHan-Pin Kuo
Dec 22, 2012·The European Respiratory Journal·Gianna CamiciottoliMassimo Pistolesi
Mar 22, 2013·Respiratory Medicine·Anke J M C LahaijeYvonne F Heijdra
Mar 25, 2014·Respiratory Physiology & Neurobiology·Elisabetta TeopompiAlfredo Chetta
Nov 2, 2014·The European Respiratory Journal·J Alberto NederDenis E O'Donnell
Apr 19, 2015·International Journal of Cardiology·Anna ApostoloPiergiuseppe Agostoni
Apr 22, 2015·Respiratory Physiology & Neurobiology·Chi-Sang PoonGang Song
Jan 23, 2016·The European Respiratory Journal·Marc MiravitllesFrancesco Blasi
Jan 23, 2016·The European Respiratory Journal·Luis Puente-MaestuSusan Ward
Mar 5, 2016·International Journal of Chronic Obstructive Pulmonary Disease·Peter LangeWilliam MacNee
Jun 13, 2016·JACC. Heart Failure·Rajeev MalhotraGregory D Lewis
Mar 10, 2017·The European Respiratory Journal·J Alberto NederDenis E O'Donnell
Sep 26, 2019·The New England Journal of Medicine·Alvar Agustí, James C Hogg

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Citations

May 1, 2021·The European Respiratory Journal·Rocco Francesco RinaldoStefano Centanni
Aug 21, 2021·Respiratory Medicine·Rocco Francesco RinaldoStefano Centanni
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·J Alberto NederDenis E O'Donnell

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