PMID: 6413658Nov 1, 1983Paper

The role of phosphatidylserine decarboxylase in brain phospholipid metabolism

Journal of Neurochemistry
M Butler, P Morell

Abstract

In brain, phosphatidylethanolamine can be synthesized from free ethanolamine either by a pathway involving the formation of CDP-ethanolamine and its transfer to diglyceride, or by base-exchange of ethanolamine with existing phospholipids. Although de novo synthesis from serine has also been demonstrated, the metabolic pathway involved is not known. The enzyme phosphatidylserine decarboxylase appears to be involved in the synthesis of much of the phosphatidylethanolamine in liver, but the significance of this route in brain has been challenged. Our in vitro studies demonstrate the existence of phosphatidylserine decarboxylase activity in rat brain and characterize some of its properties. This enzyme is localized in the mitochondrial fraction, whereas the enzymes involved in base-exchange and the cytidine pathway are localized to microsomal membranes. Parallel in vivo studies showed that after the intracranial injection of L-[G-3H]serine, the specific activity of phosphatidylserine was greater in the microsomal fractions than in the mitochondrial fraction, whereas the opposite was true for phosphatidylethanolamine. When L-[U-14C]serine and [1-3H]ethanolamine were simultaneously injected, the 14C/3H ratio in mitochondrial phosphat...Continue Reading

References

Jan 1, 1976·Advances in Experimental Medicine and Biology·L A HorrocksJ Y Chin
May 1, 1972·Journal of Neurochemistry·M A Verity
Oct 1, 1970·Chemistry and Physics of Lipids·W Stoffel
Aug 22, 1974·Biochimica Et Biophysica Acta·L M van GoldeS Fleischer
Oct 1, 1974·Canadian Journal of Biochemistry·S K Yeung, A Kuksis
Oct 1, 1968·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W Stoffel, R Henning
Nov 8, 1965·Biochimica Et Biophysica Acta·A Fleck, D Begg
Jan 1, 1967·Biochimica Et Biophysica Acta·P CerlettiR Strom
Apr 23, 1981·Biochimica Et Biophysica Acta·R K PullarkatH Reha
Oct 1, 1981·Neurochemical Research·F N LeBaronF B Jungalwala
Dec 1, 1963·Biochemical Pharmacology·R J WURTMAN, J AXELROD

❮ Previous
Next ❯

Citations

Dec 1, 1989·Molecular and Chemical Neuropathology·B W Brooksbank, M Martinez
Jul 31, 1985·Biochimica Et Biophysica Acta·H Hattori, J N Kanfer
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·V L Marcheselli, N M Giusto
Sep 9, 2000·Experimental Gerontology·M G Ilincheta de BoscheroN M Giusto
Oct 23, 2002·Journal of Neuroscience Research·Gabriela A SalvadorNorma M Giusto
Jan 1, 1986·Journal of Neurochemistry·L CorazziG Arienti
Jul 6, 2014·Progress in Lipid Research·Hee-Yong KimArthur A Spector
Jan 5, 2007·Journal of Lipid Research·Kaizong MaMireille Basselin
Apr 1, 1986·Journal of Neurochemistry·F V WhiteP Morell
Mar 1, 1987·Journal of Neurochemistry·R M GouldW Spivack
Jun 1, 1992·Alcoholism, Clinical and Experimental Research·Z Y HuP G Rhodes
Aug 22, 1985·Biochimica Et Biophysica Acta·V S Bansal, J N Kanfer
Jan 1, 1985·Progress in Lipid Research·P S Sastry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.