The role of phosphoinositide 3-kinase signaling in intestinal inflammation.

Journal of Signal Transduction
Catherine M CahillW Allan Walker

Abstract

The phosphatidylinositol 3-kinase signaling pathway plays a central role in regulating the host inflammatory response. The net effect can either be pro- or anti-inflammatory depending on the system and cellular context studied. This paper focuses on phosphatidylinositol 3-kinase signaling in innate and adaptive immune cells of the intestinal mucosa. The role of phosphatidylinositol 3-kinase signaling in mouse models of inflammatory bowel disease is also discussed. With the development of new isoform specific inhibitors, we are beginning to understand the specific role of this complex pathway, in particular the role of the γ isoform in intestinal inflammation. Continued research on this complex pathway will enhance our understanding of its role and provide rationale for the design of new approaches to intervention in chronic inflammatory conditions such as inflammatory bowel disease.

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Citations

Aug 24, 2016·FEBS Letters·Paramjeet SinghMohd Jamal Dar
Mar 1, 2014·Inflammatory Bowel Diseases·Ye YangChristian Jobin
Oct 28, 2018·Journal of Animal Physiology and Animal Nutrition·Marco ZampigaFederico Sirri
Nov 26, 2014·Chemical Reviews·Eun-Kyung LimKwangyeol Lee
Nov 21, 2020·ACS Medicinal Chemistry Letters·Dillon H MilesJenna L Jeffrey

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Methods Mentioned

BETA
biopsies
ubiquitination

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