PMID: 6412009Sep 12, 1983Paper

The role of phospholipase C in platelet responses

Life Sciences
E G Lapetina, W Siess

Abstract

Degradation of inositides induced by phospholipase C in activated platelets leads to the formation of 1,2-diacylglycerol (1,2-DG) and its phosphorylated product, phosphatidic acid (PA). We have studied the relationship between activation of phospholipase C and the appearance of specific platelet responses, such as phosphorylation of proteins, shape change, release reaction and aggregation induced by different stimuli such as thrombin, platelet-activating factor, collagen, arachidonic acid (AA) and dihomogamma linolenic acid. A low degree of platelet activation induces only shape change which is associated with partial activation of phospholipase C (formation of phosphatidic acid), and phosphorylation of both a 40K molecular weight protein (protein kinase C activation) and a 20K molecular weight protein (myosin light chain). A higher degree of platelet activation induces aggregation, release of serotonin and a higher level of phospholipase C and protein kinase C activities. Metabolism of AA occurs concomitantly to aggregation and serotonin release, but AA metabolites are not related to the shape change of human platelets. Platelet shape change and the initial activation of phospholipase C induced by thrombin or platelet-activati...Continue Reading

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Citations

Sep 15, 1986·Biochemical Pharmacology·W Siess
Jan 1, 1987·The International Journal of Biochemistry·E MalleG M Kostner
Apr 1, 1986·Prostaglandins·M A Balaa, D W Powell
Jul 31, 1998·Thrombosis Research·B Brüne, K Hanstein
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E G LapetinaP Cuatrecasas
Jan 15, 1987·European Journal of Biochemistry·H Krug, J Berndt
Aug 15, 1984·Biochimica Et Biophysica Acta·J J Myher, A Kuksis
Aug 1, 1987·Thrombosis Research·A I Woods, M A Lazzari
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S B RodanG A Rodan
Oct 1, 1986·British Journal of Clinical Pharmacology·P P GodfreyD G Grahame-Smith
Nov 15, 1984·Thrombosis Research·R C Franson, W I Rosenblum
Jul 31, 1987·Biochemical and Biophysical Research Communications·S NakashimaY Nozawa
Jul 1, 1990·Archives of Biochemistry and Biophysics·M HagiwaraH Hidaka
Apr 16, 1984·Biochemical and Biophysical Research Communications·E G Lapetina
Jun 11, 1984·FEBS Letters·D de Chaffoy de CourcellesH van Belle
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G LaffiP Gentilini
Oct 24, 2002·Blood·Margaret J StaffordCatherine J Pears
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler
Jul 1, 1985·The American Journal of Physiology·A KurtzC Bauer
Sep 12, 1983·Life Sciences·E G Lapetina, W Siess
Sep 9, 1985·Biochimica Et Biophysica Acta·C L Ashendel
Jan 1, 1989·Progress in Lipid Research·H AritaK Hanasaki
Apr 15, 1986·Thrombosis Research·M Ruggiero, E G Lapetina
Apr 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B BrüneV Ullrich
Feb 15, 1985·Biochemical and Biophysical Research Communications·F RenduF Leterrier
Sep 16, 1985·Biochemical and Biophysical Research Communications·M RuggieroE G Lapetina
May 31, 1988·Biochemical and Biophysical Research Communications·M F Crouch, E G Lapetina
Sep 17, 1984·Biochemical and Biophysical Research Communications·D de Chaffoy de CourcellesH Van Belle
Jul 24, 1987·Science·J S FlierB M Spiegelman
May 31, 1984·Biochemical and Biophysical Research Communications·S P WatsonE G Lapetina

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