The role of placenta-derived mesenchymal stem cells in healing of induced full-thickness skin wound in a mouse model

IUBMB Life
Somia H Abd-AllahRania R Abdel Kader

Abstract

We examined the effect of placenta-derived MSCs (PDMSCs) injection intraregionally and intraperitoneally on healing of induced full thickness mice skin wounds; moreover, the mechanisms by which MSCs exert their effects were also studied. Sixty female mice were divided into three groups after induction of full thickness skin wound; untreated group, wounded mice were injected with MSCs derived from human placenta intraperitoneally or intraregionally. Skin biopsies were obtained 7 and 12 days after wound incision for histological examinations, detection of vascular endothelial growth factor (VEGF) by ELISA, and estimation of expression of mouse ICAM-1, Integrin β1, Integrin β3 genes and human albumin and GAPDH genes by reverse transcription polymerase chain reaction. Human placenta derived-MSCs treated groups showed accelerated wound healing than non-treated group. VEGF, Integrin β1, and Integrin β3 levels were significantly increased in the intraregionally and intraperitoneally treated mice as compared to non-treated group at day 7 after wound induction. ICAM-1 showed significant decrease in its expression in treated groups compared with non-treated group. Interestingly, the intraperitoneal MSCs injections showed better results t...Continue Reading

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Citations

Mar 6, 2018·Journal of Cosmetic Dermatology·Mohammad-Reza Mahmoudian-SaniMassoud Saidijam
Apr 4, 2020·Tissue Engineering. Part B, Reviews·Yi-Zhou HuangHui-Qi Xie
Apr 8, 2017·Journal of Diabetes Research·Yue CaoGuixia Wang
Aug 15, 2020·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Ling-Li JiXu Chen
Mar 8, 2021·Drug Delivery and Translational Research·Hamid Reza AghayanBabak Arjmand
Mar 16, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Pratheesh D MankuzhyTaru Guttula Sharma
Sep 30, 2018·Advanced Drug Delivery Reviews·Austin P VeithAaron B Baker
Apr 26, 2021·The Journal of Surgical Research·Shaohang ChengLili Du
Aug 8, 2021·Cells·Raquel Guillamat-Prats
Oct 12, 2021·Frontiers in Bioengineering and Biotechnology·Melanie PichlsbergerIngrid Lang-Olip

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