The Role of Plasma Chromogranin A as Assessment of Treatment Response in Non-functioning Gastroenteropancreatic Neuroendocrine Tumors

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Moonjin KimSeung Tae Kim

Abstract

Chromogranin A (CgA) has been considered to be valuable not only in the diagnosis but also in monitoring the disease response to treatment. However, only a few studies have been published on this issue. We purposed to evaluate whether biochemical response using plasma CgA level is reliable in concordance with the clinical response of grade 1-3 nonfunctiong gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Between March 2011 and September 2013, a total of 27 cases in 18 patients were analysed, clinically and radiologically while serial CgA tests were also conducted during treatment. Tumor responses were defined by both Response Evaluation Criteria in Solid Tumors (RECIST) criteria ver. 1.1 and biochemical criteria based on the CgA level. Among the 27 cases analysed, no difference in the basal CgA level was observed with regard to gender, primary tumor site, tumor grade (World Health Organization classification), liver metastasis, number of metastatic site, and line of chemotherapy. The overall response rate (RR) by RECIST criteria ver. 1.1 was six out of the 27 cases (22.2%) and eight out of the 27 cases (29.6%) for biochemical RR. The overall concordance rates of the response based on RECIST and biochemical criteria were...Continue Reading

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Citations

Jan 4, 2017·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Yoshihide NannoYonson Ku
Aug 12, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Daphne M V HuizingMarcel P M Stokkel
Jul 3, 2019·Frontiers in Endocrinology·Marco TatulloGianrico Spagnuolo

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