PMID: 6160726Sep 1, 1980Paper

The role of plasma membrane Ca++-Mg++ activated adenosine triphosphatase of rat mast cells on histamine release

Acta Pharmacologica Et Toxicologica
N Chakravarty

Abstract

The role of a Ca++-MG++ activated ATPase, demonstrated on the outer surface of rat peritoneal mast cells, on histamine release induced by antigen (anaphylactic reaction), compound 48/80 and ionophore A23187 has been studied. A high level of the enzyme activity is retained at the optimal pH for histamine release induced by the three releasing agents. The effect of fourteen inhibitors of ATPase has been studied, viz. quinidine, fluoride, platinum salt, suramin, ethacrynic acid, ethyl alcohol, N-ethylmaleimide, Mn++, Ni++, ADP, AMP and the flavones: kaempferol, quercetin, morin. All the inhibitors, which caused varying degrees of inhibition of ATPase, also inhibited histamine release. The inhibition of the enzyme was competitive with ADP, AMP, ethacrynic acid, suramin and morin and non-competitive with the others. The degree of inhibition of ATPase and of histamine release tended to be similar with six inhibitors. With the others the extent of the inhibition of the release and of the enzyme varied. But a marked inhibition of the enzyme was always associated with a pronounced inhibition of histamine release. ATP in lower concentrations (10-20 microM) has been shown to potentiate histamine release induced by all the three releasers,...Continue Reading

References

Aug 15, 1977·Biochimica Et Biophysica Acta·C M Fewtrell, B D Gomperts
May 15, 1979·Experientia·P D TurlapatyB M Altura
Aug 1, 1973·Acta Physiologica Scandinavica·N ChakravartyP Sen
Aug 1, 1961·Biochemical Pharmacology·A M ROTHSCHILDM ROCHA E SILVA
Feb 1, 1961·Experimental Cell Research·B UVNAS, I L THON
May 1, 1965·The Journal of Cell Biology·N Chakravarty, E Zeuthen
May 1, 1965·The Journal of Cell Biology·N Chakravarty

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Citations

Jun 1, 1990·Acta Physiologica Scandinavica·N Chakravarty
Apr 1, 1986·Agents and Actions·N Chakravarty, W J Yu
Apr 1, 1984·Agents and Actions·N Chakravarty, W J Yu
Apr 1, 1981·Agents and Actions·N Chakravarty, E H Nielsen
Sep 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R R FerreiraJ C Gomes
Feb 25, 1999·American Journal of Respiratory Cell and Molecular Biology·E S SchulmanA Pelleg
Nov 19, 2009·Purinergic Signalling·Elena Bulanova, Silvia Bulfone-Paus
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·P E Alm
Jan 1, 1987·Pharmacology & Toxicology·T Johansen
Apr 1, 1982·Agents and Actions·N Chakravarty
Sep 19, 2002·American Journal of Therapeutics·Amir Pelleg, Edward S Schulman
Jan 1, 1983·Pharmacology & Therapeutics·B R Creese
Oct 27, 1986·Life Sciences·N Chakravarty
Feb 1, 1990·Experimental Cell Research·N ChakravartyE H Nielsen

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