PMID: 8458192Mar 1, 1993Paper

The role of plasma non-esterified fatty acids during exercise in type 2 diabetes mellitus

Diabetic Medicine : a Journal of the British Diabetic Association
T S BerrishM Walker

Abstract

Elevated fasting plasma non-esterified fatty acid (NEFA) levels have been reported in Type 2 diabetes. We examined whether such changes persist during low-grade exercise and influence carbohydrate metabolism. Eight Type 2 diabetic patients with moderate glycaemic control and eight healthy controls received the anti-lipolytic agent, acipimox, or placebo on separate occasions before exercising for 45 min at 35% pre-determined VO2max. Fasting plasma NEFA levels were similar (0.40 +/- 0.06 (SEM) and 0.45 +/- 0.05 mmol l-1; healthy and Type 2 diabetic subjects) following placebo, and increased to comparable levels with exercise (0.73 +/- 0.07 and 0.73 +/- 0.10 mmol l-1). Acipimox lowered basal NEFA levels (0.14 +/- 0.03 and 0.28 +/- 0.04 mmol l-1; both p < 0.05 vs placebo), and prevented the rise with exercise. Blood glucose (p < 0.001) and serum insulin (p < 0.01) levels were higher in the Type 2 diabetic patients (vs controls) for both treatments. Whole body lipid oxidation increased from baseline to a comparable degree with exercise following placebo (3.2 +/- 0.3 and 2.8 +/- 0.3 mg kg-1 min-1; healthy and Type 2 diabetic subjects, both p < 0.02). Although less marked, the same was also observed following acipimox (2.0 +/- 0.4 and...Continue Reading

References

Nov 20, 1975·The New England Journal of Medicine·P Felig, J Wahren
Sep 1, 1991·Clinical Science·M WalkerK G Alberti
Mar 1, 1988·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·J HarrisonK G Alberti
Aug 1, 1988·British Journal of Industrial Medicine·J J WellerJ E Cotes
Mar 1, 1986·Journal of Applied Physiology·E RavussinE S Horton
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·E FrazeG M Reaven
Mar 1, 1985·Diabetes Care·G Sundkvist, B Lilja
Jul 1, 1967·Journal of Applied Physiology·R J HavelN L Jones
Aug 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K N Frayn
Dec 1, 1980·Clinical Pharmacology and Therapeutics·L M FuccellaC R Sirtori
Jan 1, 1984·The Journal of Automatic Chemistry·D P Knox, D G Jones

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.