PMID: 11604562Oct 18, 2001Paper

The role of platelet collagen receptor (glycoprotein Ia/IIa; integrin alpha2 beta1) polymorphisms in thrombotic disease

Current Opinion in Hematology
Thomas J Kunicki

Abstract

Differences in rates of platelet activation induced by extracellular matrix components such as collagens markedly influence normal hemostasis and the pathologic outcome of thrombosis. Thus, platelet collagen receptors, the integrin alpha2beta1, glycoprotein VI, and the glycoprotein Ib complex, represent unexploited targets of pharmacologic control. Polymorphisms of these receptors are now understood as factors that potentially contribute to thrombotic risk. There is substantial evidence that the GPIbalpha variable number of tandem repeats A or B alleles, the -5C allele of GPIbalpha, and the integrin alpha2 allele 1 (T807) each contribute to risk for and morbidity from thrombotic disease. The extent of their individual contributions is disputed. More well-designed, large, prospective, genetic and epidemiologic studies are needed to clarify the role of these and other platelet receptor polymorphisms, and additional in vitro studies are needed to provide a sound biologic explanation for the outcomes of clinical correlations.

References

Sep 1, 1991·Somatic Cell and Molecular Genetics·M JaspersJ J Cassiman
Aug 1, 1990·The Journal of Cell Biology·M J IgnatiusL F Reichardt
Nov 15, 1993·Thrombosis Research·L F MortonM J Barnes
Jul 26, 1996·The Journal of Biological Chemistry·J GibbinsS P Watson
Jul 8, 2000·Stroke; a Journal of Cerebral Circulation·A P ReinerD S Siscovick
Feb 15, 2001·Annals of Internal Medicine·U RauchJ H Chesebro
Feb 24, 2001·Diabetes, Obesity & Metabolism·L M Brass
Mar 29, 2001·American Journal of Preventive Medicine·T S HarwellS D Helgerson

❮ Previous
Next ❯

Citations

Feb 25, 2006·Nature Reviews. Cancer·Sam M Janes, Fiona M Watt
Feb 13, 2003·The Journal of Cell Biology·Richard D EvansFiona M Watt
Apr 19, 2008·Human Mutation·A BersanoL Candelise
Nov 4, 2004·Journal of Structural Biology·Fengzhi JiangDaniel J Müller
Sep 4, 2004·The Journal of Biological Chemistry·Pia R-M SiljanderRichard W Farndale
Sep 29, 2017·Cancers·Marion LavergnePierre H Mangin
Jun 11, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nadine AjzenbergJoelle Benessiano
Jun 22, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Takaki Koide
May 4, 2021·Frontiers in Cell and Developmental Biology·Wolfgang M J ObermannJohannes A Eble

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.