The role of platelets in acute kidney injury

Nature Reviews. Nephrology
Marcel P B JansenJoris J T H Roelofs

Abstract

Acute kidney injury (AKI), a major public health problem associated with high mortality and increased risk of progression towards end-stage renal disease, is characterized by the activation of intra-renal haemostatic and inflammatory processes. Platelets, which are present in high numbers in the circulation and can rapidly release a broad spectrum of bioactive mediators, are important acute modulators of inflammation and haemostasis, as they are the first cells to arrive at sites of acute injury, where they interact with endothelial cells and leukocytes. Diminished control of platelet reactivity by endothelial cells and/or an increased release of platelet-activating mediators can lead to uncontrolled platelet activation in AKI. As increased platelet sequestration and increased expression levels of the markers P-selectin, thromboxane A2, CC-chemokine ligand 5 and platelet factor 4 on platelets have been reported in kidneys following AKI, platelet activation likely plays a part in AKI pathology. Results from animal models and some clinical studies highlight the potential of antiplatelet therapies in the preservation of renal function in the context of AKI, but as current strategies also affect other cell types and non-platelet-de...Continue Reading

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Citations

Aug 8, 2019·Annals of Intensive Care·Joana Gameiro, José António Lopes
Jan 17, 2020·Nature Reviews. Nephrology·Sydney C W Tang, Wai Han Yiu
Sep 23, 2020·Nature Reviews. Nephrology·David A C MessererMarkus Huber-Lang
Mar 19, 2019·Critical Care Medicine·Anne-Cornélie J M de Pont, Meint Volbeda
Jan 13, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Elena CampelloPaolo Simioni
Feb 27, 2021·Clinical and Translational Medicine·Wei ChenDianwen Ju
Apr 22, 2021·Burns : Journal of the International Society for Burn Injuries·Emre KarakayaMehmet Haberal
May 7, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bassant M El-MokademAyman A Soubh
Sep 18, 2021·Journal of the American Heart Association·Miriam T RademakerA Mark Richards

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Methods Mentioned

BETA
dot blot
coronary bypass

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