The incidence of asthma is on the increase worldwide, yet the pathogenesis of this disease is still not fully understood. Many recent drug trials have had disappointing results, thus fuelling the need for more research to be undertaken in this area. Substantial evidence suggests an important role for platelets in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, eczema, allergic rhinitis and asthma. In asthma, platelets have been found to actively participate in most of its main features, including bronchial hyperresponsiveness, bronchoconstriction, airway inflammation and airway remodelling. It has recently become clear that platelet-release products, as well as the expression of adhesion molecules on the platelet surface and the ability to undergo chemotaxis, are all involved in these processes. This review focuses on both experimental and clinical studies available to date that have investigated the role of platelets in the pathophysiology of asthma. Taken together, the evidence points toward platelets being an attractive new target in the area of asthma research; a target with much-needed novel therapeutic potential.
Comparison of a beta 2-agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma
PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle
The requirement for platelets in allergen-induced late asthmatic airway obstruction. Eosinophil infiltration and heightened airway responsiveness in allergic rabbits
Platelets, platelet-derived growth factor, growth control, and their interactions with the vascular wall
Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man
Platelet activation during exercise induced asthma: effect of prophylaxis with cromoglycate and salbutamol
Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists
Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen
Preliminary studies on the inflammatory stimulus induced proteins in mouse resident peritoneal macrophages
Pharmacological modulation of the respiratory and haematological changes accompanying active anaphylaxis in the guinea-pig
Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution
In vitro release of arachidonic acid metabolites, glutathione peroxidase, and oxygen-free radicals from platelets of asthmatic patients with and without aspirin intolerance
Allergen exposure in acute asthma causes the release of platelet-activating factor (PAF) as demonstrated by the desensitization of platelets to PAF
Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma
Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS)
Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits
Platelets and inflammation: role of platelet-derived growth factor, adhesion molecules and histamine
Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology
Correlative alteration of thromboxane A2 with antigen-induced bronchoconstriction and the role of platelets as a source of TXA2 synthesis in guinea pigs: effect of DP-1904, an inhibitor of thromboxane synthetase
Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)
Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo
Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials
Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research
Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids
Expression of platelet-derived endothelial cell growth factor and vascularity in the nasal mucosa from allergic rhinitis
Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol), in asthma
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
Platelets stimulate airway smooth muscle cell proliferation through mechanisms involving 5-lipoxygenase and reactive oxygen species
Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease
Expression of surface platelet receptors (CD62P and CD41/61) in horses with recurrent airway obstruction (RAO)
Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration
Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects
Analysis of serum polyunsaturated fatty acid metabolites in allergic bronchopulmonary aspergillosis.
Platelet reactivity in patients with chronic kidney disease undergoing percutaneous coronary intervention
Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.
Effect of antigen challenge on dynamics of CD62P and CD41/61 expression on platelets in horses with recurrent airway obstruction (RAO)
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.