The role of platelets in the pathophysiology of asthma

Platelets
K N Kornerup, C P Page

Abstract

The incidence of asthma is on the increase worldwide, yet the pathogenesis of this disease is still not fully understood. Many recent drug trials have had disappointing results, thus fuelling the need for more research to be undertaken in this area. Substantial evidence suggests an important role for platelets in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, eczema, allergic rhinitis and asthma. In asthma, platelets have been found to actively participate in most of its main features, including bronchial hyperresponsiveness, bronchoconstriction, airway inflammation and airway remodelling. It has recently become clear that platelet-release products, as well as the expression of adhesion molecules on the platelet surface and the ability to undergo chemotaxis, are all involved in these processes. This review focuses on both experimental and clinical studies available to date that have investigated the role of platelets in the pathophysiology of asthma. Taken together, the evidence points toward platelets being an attractive new target in the area of asthma research; a target with much-needed novel therapeutic potential.

References

Mar 1, 1992·The American Review of Respiratory Disease·F J AverillM C Liu
Jan 1, 1989·International Archives of Allergy and Applied Immunology·M PretolaniB B Vargaftig
Apr 1, 1987·British Medical Bulletin·B B Vargaftig, P G Braquet
Feb 9, 1985·Lancet·C P PageJ Morley
Feb 9, 1985·Lancet·P GreseleG G Nenci
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·C E Reed
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Apr 1, 1988·The American Review of Respiratory Disease·B ArnouxJ Benveniste
Nov 1, 1987·Journal of Applied Physiology·R W BolinR K Albert
Nov 1, 1986·The American Review of Respiratory Disease·A TaytardP Freour
Jun 1, 1985·Thorax·P W IndC T Dollery
Nov 17, 1984·Lancet·J MorleyC P Page
Dec 1, 1993·Journal of Pharmacological and Toxicological Methods·E M MinshallC P Page
Jan 1, 1993·The Journal of Allergy and Clinical Immunology·H YamamotoY Dohi
Apr 1, 1993·The Journal of Allergy and Clinical Immunology·P GreseleG G Nenci
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·M RobuschiS Bianco
Jan 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P F MannaioniE Masini
Mar 14, 1998·Chest·C MoritaniM Yamakido
Dec 23, 1999·Current Opinion in Pulmonary Medicine·J V FahyH A Boushey
Mar 18, 2000·Thorax·S O ShaheenP G Burney
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·S T HolgateD Davies
Nov 9, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S MoriH Saito
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·N J VanackerR A Pauwels
Nov 15, 2001·Australian Family Physician·J Burdon
Jul 18, 2002·Trends in Pharmacological Sciences·Domenico Spina, Clive P Page
Jul 27, 2002·The Lancet Oncology·G F NashA K Kakkar
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas W LukacsLloyd M Stoolman

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Citations

Feb 10, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Slavica DodigRenata Zrinski-Topić
Aug 28, 2014·American Journal of Respiratory and Critical Care Medicine·Emiko OnoUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Apr 18, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jason E LangJohn J Lima
Jan 10, 2012·Experimental Cell Research·Ann-Charlotte B Svensson HolmEva G Lindström
Mar 31, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Mahmut DogruSeda Ozturkmen
May 31, 2011·Allergologia et immunopathologia·T TuncelN Uzuner
Mar 24, 2010·Pulmonary Pharmacology & Therapeutics·Lineu BaldisseraEdson Antunes
Mar 13, 2015·Experimental Hematology & Oncology·Antoine DewitteJean Ripoche
Apr 9, 2016·The Journal of Allergy and Clinical Immunology·Tomohiro TakedaAkio Matsuda
Apr 22, 2011·Platelets·Vanja Radišić BiljakTihana Žanić Grubišić
Jan 5, 2011·Platelets·Ann-Charlotte B Svensson HolmEva G Lindström
Mar 29, 2013·Platelets·Ann-Charlotte B Svensson HolmEva G Lindström
Jul 1, 2015·Allergy, Asthma & Immunology Research·Dong Young KimRobert P Schleimer
Jun 9, 2015·The Journal of Allergy and Clinical Immunology·Marco IdzkoClive Page
Feb 11, 2015·Veterinary Immunology and Immunopathology·Alicja Iwaszko-SimonikAleksandra Pliszczak-Krol
Jan 23, 2015·Frontiers in Immunology·Angèle GrosBenoît Ho-Tin-Noé
Aug 5, 2016·Physiological Reviews·Elizabeth A MiddletonGuy A Zimmerman
Jan 28, 2018·Respiratory Research·Ashraf FawzyUNKNOWN SPIROMICS and COPDGene Investigators
Feb 28, 2008·Nature Reviews. Immunology·Hamida Hammad, Bart N Lambrecht
Jun 19, 2010·Journal of Applied Physiology·Kristin N KornerupClive P Page
Jul 30, 2011·Rheumatology International·Armen Yuri GasparyanGeorge D Kitas
Sep 29, 2011·FEBS Letters·Sagit CohenNoah Isakov
Jan 21, 2012·Blood·J Daan de BoerTom van der Poll
May 21, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gonul BuyukyilmazYildiz Dallar
Oct 3, 2019·Physiology·Emma Lefrançais, Mark R Looney
Jan 12, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Phoomphut SangaphunchaiLucy C Fairclough
Mar 15, 2020·Journal of Leukocyte Biology·Mackenzie E Coden, Sergejs Berdnikovs
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam WrightCatherine Vial
Jan 23, 2021·International Journal of Molecular Sciences·José A CañasVictoria del Pozo
Sep 29, 2019·The Journal of Allergy and Clinical Immunology·Yoshimasa ImotoRobert P Schleimer
Aug 20, 2021·Journal of Asthma and Allergy·Jack T WombleJennifer L Ingram
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Mohamad ChebboDelphine Gras

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