The role of polyamines in interferon and retinoic acid mediated synergistic antiproliferative action

Cancer Letters
C MarthG Daxenbichler

Abstract

Retinoic acid alone has no effect on the human breast cancer cell line BT-20 but can amplify the antiproliferative action of interferon-gamma (IFN-gamma). In our system ornithine decarboxylase (ODC) activity correlates well with growth rate; it was investigated whether the antiproliferative effects of IFN-gamma and IFN-gamma plus retinoic acid could be attributed to suppression of ODC activity. The ODC inhibitor difluoromethylornithine (DFMO), which is active as a single agent did not enhance growth inhibition induced by the biological response modifiers. The substitution of the BT-20 cells with putrescine, the product of the enzymatic reaction mediated by ODC, reversed DFMO induced antiproliferative action. On the other hand putrescine did not affect the proliferation of BT-20 cells treated with interferon alone or in combination with retinoic acid.

References

Dec 15, 1987·International Journal of Cancer. Journal International Du Cancer·C MarthG Daxenbichler
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·M D Bregman, F L Meyskens
Mar 1, 1986·The Biochemical Journal·A E Pegg
Apr 14, 1987·Biochemical and Biophysical Research Communications·L Alhonen-HongistoJ Jänne
Jul 16, 1985·Biochemical and Biophysical Research Communications·S GrantP B Fisher
Sep 1, 1985·European Journal of Cancer & Clinical Oncology·A N Kingsnorth, H M Wallace
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor

❮ Previous
Next ❯

Citations

May 1, 1991·Molecular and Cellular Endocrinology·G Scalabrino, E C Lorenzini
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S WongG Y Minuk
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M ShinW K Hong
Apr 22, 1991·International Journal of Cancer. Journal International Du Cancer·L WuarinN Sidell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
M D IslaA Tres
© 2022 Meta ULC. All rights reserved