The role of polyfusomes in generating branched chains of cystocytes during Drosophila oogenesis

Developmental Genetics
P D Storto, R C King

Abstract

Three-dimensional models were constructed utilizing the information gained from electron micrographs of serial sections of two clones of cystocytes undergoing their terminal divisions. In each clone a polyfusome connected all eight cystocytes together. Each of the spindles was oriented so that one pole touched the polyfusomes, while the other pointed away from it. This positioning of spindles ensures that one cell of each dividing pair retains all previously formed canals, while the other receives none. The two cells that eventually come to contain the maximum number of canals and fusomal material are the ones that differentiate as pro-oocytes, while the others become nurse cells. The orientation of each spindle suggests that the polyfusome formed at one division determines the placement of the cytoskeletal fibers that anchor the spindles formed at the next division. There is a centripetal gathering together of new canals following each cycle of cystocyte division, which is thought to result from the subsequent contraction of the polyfusomal system. Females homozygous for the otu1 mutation are characterized by ovarian tumors, which result when germarial cystocytes undergo supernumerary divisions and fail to differentiate into e...Continue Reading

References

Jan 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R C King, P D Storto
Jan 1, 1988·Developmental Genetics·P D Storto, R C King
Jan 1, 1986·Developmental Genetics·R C KingP S Nicolazzo
Aug 29, 1970·Nature·J Gibson
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·C C Dapples, R C King
Jan 1, 1967·Journal of Morphology·E A KochR C King
Apr 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Patrick Daniel Storto, Robert Charles King

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Citations

Sep 22, 2006·Systems Biology·N YakobyS Y Shvartsman
Aug 5, 2004·Molecular Biology of the Cell·Erik L SnappMary A Lilly
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Dec 19, 2015·Hormone Molecular Biology and Clinical Investigation·Onder CelikSudenaz Celik
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Mar 3, 2020·Frontiers in Cell and Developmental Biology·Taylor D HinnantElizabeth T Ables
Mar 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·L Billett, N G Brink
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Dec 12, 2003·Genetics·Pamela K Mulligan
Oct 28, 1994·Science·L Cooley, W E Theurkauf

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