The Role of postoperative external beam radiotherapy for differentiated thyroid carcinoma: A Systematic review and meta-analysis.

Head & Neck
Luisa E JacominaMichael Benedict A Mejia

Abstract

The indications for external beam radiotherapy (RT) in differentiated thyroid carcinomas (DTC) are still undefined. The objective of this study was to synthesize current evidence defining the role of postoperative RT in patients with DTC. A systematic review and meta-analysis were done. Included studies compared oncologic outcomes and toxicity of RT vs no RT in patients with DTC. Nine studies were included, two prospective and seven retrospective cohorts. RT improved 5-year locoregional recurrence-free survival but not overall survival and distant metastasis failure-free survival. The locoregional control benefit was seen in patients at increased risk for recurrence, including those with advanced age, locoregionally advanced disease, gross or microscopic residual tumor, and structural invasion. Serious RT-related acute and late toxicities were rare. Available evidence suggests that postoperative RT can improve locoregional control in high-risk DTC with acceptable toxicity. Further prospective studies are warranted.

References

Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Dec 4, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Andreas SchuckNormann Willich
Dec 20, 2005·American Journal of Otolaryngology·Kenyon M MeadowsWilliam M Mendenhall
Mar 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Ki Chang KeumGwi Eon Kim
Aug 5, 2008·International Journal of Radiation Oncology, Biology, Physics·Stephanie A TerezakisNancy Y Lee
Dec 20, 2008·International Journal of Radiation Oncology, Biology, Physics·David L SchwartzAdam S Garden
Oct 19, 2013·Radiation Oncology Journal·Jeanny KwonDo Joon Park
Oct 7, 2014·International Journal of Cancer. Journal International Du Cancer·Carlo La VecchiaEva Negri
Sep 4, 2015·Head & Neck·Jonathan M FusseyHisham Mehanna
Jan 13, 2016·Endocrinology and Metabolism·Tom Edward N LoPatricia Deanna D Maningat
Nov 4, 2017·JAMA Otolaryngology-- Head & Neck Surgery·Samantha TamMark E Zafereo
Jan 9, 2019·Head & Neck·Uchechukwu C MegwaluYifei Ma
Oct 24, 2019·The Cochrane Database of Systematic Reviews·Miranda CumpstonJames Thomas

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