PMID: 2835Feb 1, 1976

The role of potassium in the control of ammonium excretion during starvation

Metabolism: Clinical and Experimental
D G SapirJ W Ryan

Abstract

Administration of KC1 0.5 mmol/kg/day to subjects undergoin prolonged starvation reduced daily urinary ammonium and beta-hydroxybutyrate excretion by one-third. These changes were accompanied by an improvement in potassium balance and an increased rate of chloride excretion. A similar fall in ammonium excretion occurred in a second group of subjects after administration of KHCO3 0.5 mmol/kg/day. Ketone body and bicarbonate excretion remained unchanged in this group while potassium balance improved. In both the first and second groups urine pH fell significantly as the rate of excretion of urinary buffer (ammonium) decreased. When the dose of KHCO3 was increased to 1.5-2.0 mmol/kg/day in fasting subjects, the urine was alkalinized, and ammonium excretion fell to negligible levels, resulting in nitrogen sparing of 2.0 g/day. The results indicate that one-half of the increase in ammonium excretion observed in starvation is due to potassium deficiency. Nitrogen wastage caused by losses of urinary ammonium during starvation can be virtually eliminated by potassium supplementation and urinary alkalinization. The decrease in beta-hydroxybutyrate excretion after potassium chloride administration was not caused by a fall in the rate of ...Continue Reading

References

Jan 1, 1975·Metabolism: Clinical and Experimental·D G Sapir, O E Owen
Aug 1, 1972·The Journal of Clinical Investigation·D G SapirW G Walker
Apr 1, 1970·The Journal of Clinical Investigation·R L Tannen
Mar 1, 1969·The Journal of Clinical Investigation·O E OwenG F Cahill
Mar 1, 1953·The Journal of Clinical Investigation·W B SCHWARTZ, A S RELMAN
Feb 1, 1956·The Journal of Clinical Investigation·J ORLOFF, R W BERLINER

Citations

May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·M EliaG Neale
Sep 17, 1998·The New England Journal of Medicine·V L Hood, R L Tannen
Aug 1, 1991·The American Journal of the Medical Sciences·R Gougeon-ReyburnE B Marliss
Feb 1, 1982·Kidney International·R S SleeperH G Preuss
Jun 1, 1977·Kidney International·R L Tannen
Aug 1, 1997·Kidney International·R M CohenP C Fernandez
Jun 1, 1989·Diabetes/metabolism Reviews·M L Halperin, S Cheema-Dhadli
Jun 1, 1989·Diabetes/metabolism Reviews·V L Hood, R L Tannen

Related Concepts

Anion Gap
Ammonia
Carbonic Acid Ions
D-Glutamine
Hydrogen-Ion Concentration
Ketone Bodies
Kidney
Nitrogen
Potassium
Slow-K

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