The role of PP5 and PP2C in cardiac health and disease.

Cellular Signalling
Joachim NeumannUlrich Gergs

Abstract

Protein phosphatases are important, for example, as functional antagonists of β-adrenergic stimulation of the mammalian heart. While β-adrenergic stimulations increase the phosphorylation state of regulatory proteins and therefore force of contraction in the heart, these phosphorylations are reversed and thus force is reduced by the activity of protein phosphatases. In this context the role of PP5 and PP2C is starting to unravel. They do not belong to the same family of phosphatases with regard to sequence homology, many similarities with regard to location, activation by lipids and putative substrates have been worked out over the years. We also suggest which pathways for regulation of PP5 and/or PP2C described in other tissues and not yet in the heart might be useful to look for in cardiac tissue. Both phosphatases might play a role in signal transduction of sarcolemmal receptors in the heart. Expression of PP5 and PP2C can be increased by extracellular stimuli in the heart. Because PP5 is overexpressed in failing animal and human hearts, and because overexpression of PP5 or PP2C leads to cardiac hypertrophy and KO of PP5 leads to cardiac hypotrophy, one might argue for a role of PP5 and PP2C in heart failure. Because PP5 and...Continue Reading

References

Jan 1, 1991·Journal of Biochemistry·T TakasagoM Shigekawa
Jan 1, 1991·Annual Review of Physiology·E MurphyM Lieberman
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S TamuraS Tsuiki
Jan 1, 1986·Advances in Enzyme Regulation·R A HarrisA C Han
Oct 17, 1985·Biochimica Et Biophysica Acta·K Kato, S Kimura
Jul 1, 1995·The Journal of Clinical Investigation·T YamazakiK Tobe
Aug 31, 1995·Biochimica Et Biophysica Acta·Y KimH R Matthews
Apr 20, 1995·Archives of Biochemistry and Biophysics·S KatoS Tamura
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Chinkers
Jan 14, 1994·Biochemical and Biophysical Research Communications·S SalvatoriF Meggio
Jan 17, 1996·Biochemical and Biophysical Research Communications·X XuA Zetterberg
Mar 7, 1996·Biochemical and Biophysical Research Communications·H FukudaM Nagao
Feb 9, 1996·The Journal of Biological Chemistry·R D HannanL I Rothblum
Sep 1, 1996·Journal of Neurochemistry·Y GuY Ihara
Jul 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M Chinkers
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·S M TravisM J Welsh
May 13, 1998·The Biochemical Journal·K KusudaS Tamura
Jul 31, 1998·FEBS Letters·A E MarleyR K Beri
May 7, 1999·Brain Research Bulletin·S S GillP F McGuire

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