The role of prefrontal-subcortical circuitry in negative bias in anxiety: Translational, developmental and treatment perspectives.

Brain and Neuroscience Advances
Christina O Carlisi, Oliver J Robinson

Abstract

Anxiety disorders are the most common cause of mental ill health in the developed world, but our understanding of symptoms and treatments is not presently grounded in knowledge of the underlying neurobiological mechanisms. In this review, we discuss accumulating work that points to a role for prefrontal-subcortical brain circuitry in driving a core psychological symptom of anxiety disorders - negative affective bias. Specifically, we point to converging work across humans and animal models, suggesting a reciprocal relationship between dorsal and ventral prefrontal-amygdala circuits in promoting and inhibiting negative bias, respectively. We discuss how the developmental trajectory of these circuits may lead to the onset of anxiety during adolescence and, moreover, how effective pharmacological and psychological treatments may serve to shift the balance of activity within this circuitry to ameliorate negative bias symptoms. Together, these findings may bring us closer to a mechanistic, neurobiological understanding of anxiety disorders and their treatment.

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Citations

Jan 30, 2020·Social Cognitive and Affective Neuroscience·Fenne M SmitsElbert Geuze
Aug 7, 2020·Social Cognitive and Affective Neuroscience·Giulia GalliMaria Concetta Pellicciari
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Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaux M KenwoodHelen Barbas

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Methods Mentioned

BETA
cognitive-behavioural therapy

Software Mentioned

ENIGMA

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