PMID: 8958445Sep 1, 1996Paper

The role of prenylation in G-protein assembly and function

Cellular Signalling
J B Higgins, P J Casey

Abstract

Heterotrimeric guanine nucleotide-binding regulatory proteins (G-proteins) are vital components of numerous signal transduction pathways, including sensory and hormonal response systems. G-proteins transduce signals from heptahelical transmembrane receptors to downstream effectors. The localization of a G-protein to the plasma membrane, as well as its interaction with the appropriate receptor and effector, are essential for its function. In addition, the association of a G-protein's subunits to form its trimer is required for interaction with its receptor. The G-protein gamma subunits (G gamma) are subject to a set of carboxyl-terminal processing events that include prenylation of a cysteine, proteolysis, and methylation. Recent advances which elucidate the contributions that the post-translational modifications of the G gamma subunit have on the assembly, membrane association, and function of the G-protein trimer reveal that these modifications are required for important protein-protein, in addition to membrane-protein, interactions.

References

Jan 1, 1992·Annual Review of Biochemistry·S Clarke
Sep 18, 1992·Cell·W J Tang, A G Gilman
Jan 1, 1991·Annual Review of Biochemistry·H G DohlmanR J Lefkowitz
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Pérez-SalaR R Rando
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H K YamaneJ A Glomset
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyP C Sternweis
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyA G Gilman
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R K LaiR R Rando
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J E BussB M Sefton
Jun 30, 1995·The Journal of Biological Chemistry·U MendeE J Neer
May 1, 1995·Trends in Biochemical Sciences·G MilliganA I Magee
Jan 13, 1995·The Journal of Biological Chemistry·P B WedegaertnerH R Bourne
Apr 1, 1994·Current Opinion in Cell Biology·P J Casey
Aug 23, 1994·Biochemistry·C A Parish, R R Rando
Aug 24, 1993·Biochemistry·T C ThomasE J Neer
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E LinderS M Mumby
Apr 15, 1993·The Biochemical Journal·M ParentiA I Magee
Jan 1, 1996·Annual Review of Biochemistry·F L Zhang, P J Casey
Jul 1, 1993·Trends in Cell Biology·J Iñiguez-LluhiA G Gilman

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Citations

Apr 22, 2008·Molecular Neurobiology·Nikolai O Artemyev
Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Peter H Sugden
Jun 14, 2003·Pharmacology & Therapeutics·Anthony S WierzbickiAlbert Ferro
Jun 15, 2007·Biochemistry·Yannick MarrariPhilip B Wedegaertner
Jun 18, 2002·Plant Physiology·Hemayet UllahAlan M Jones
Mar 21, 2001·Antimicrobial Agents and Chemotherapy·T L Gower, B S Graham
Sep 2, 2005·Molecular and Cellular Biology·Jaco C KnolPeter J M van Haastert
Oct 16, 2009·Journal of Lipid Research·Norma M GiustoMónica G Ilincheta de Boschero
Dec 1, 2011·Science China. Chemistry·Xiaomu Guan, Carol A Fierke
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Didier LeysRegis Bordet
Apr 12, 2008·Biochimica Et Biophysica Acta·Oliver VöglerPablo V Escribá
Oct 28, 2006·Biochimica Et Biophysica Acta·Pablo V EscribáOliver Vögler
Jun 3, 2016·Journal of Veterinary Internal Medicine·M L ByrumT M Fan
Jun 26, 2003·Thérapie·Pierre AmbrosiGilles Bouvenot
Sep 30, 2010·Plasmid·Mario C Salinas-Carmona, María R Rocha-Pizaña
Aug 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Keira L Watts, Monica A Spiteri
Feb 15, 2013·Pharmacological Reviews·Shahriar M KhanTerence E Hébert
Mar 1, 2003·The Journal of Biological Chemistry·Satoshi Takida, Philip B Wedegaertner
Jan 29, 2020·Molecular Neurobiology·Jairus M ReddyDiAnna L Hynds
Feb 19, 2020·Translational Psychiatry·Anita L PinnerJames H Meador-Woodruff
Feb 15, 2021·Cellular Signalling·Mithila TennakoonAjith Karunarathne
Aug 1, 1997·Biochemical Pharmacology·J D Hildebrandt
Jan 16, 1998·Cellular Signalling·N Dascal
Jun 10, 2021·Molecular Biology of the Cell·Mithila TennakoonAjith Karunarathne

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