The role of primary MLC of the non HLA-D/DR determinant PL3A

Tissue Antigens
A Termijtelen, J J van Rood

Abstract

To test the influence in primary MLC of the newly PLT defined determinant PL3A (Termijtelen et al. 1980), 11 Dw3/DR3 homozygous individuals were tested in an MLC matrix. Two groups of mutually negative cells were detailed. The results appeared to correlate with the presence of PL3A. Cells from group 2 were stimulated by cells from group 1, but the reverse reactions were negative. A genetic model for this "one way" stimulation, observed in MLC as well as PLT, is discussed. We suggest that PL3A, which causes strong stimulation in PLT, also plays a role in primary MLC.

References

Feb 1, 1977·Journal of Immunogenetics·A B BijnenJ J van Rood
Oct 1, 1972·European Journal of Immunology·V P EijsvoogelP T Schellekens

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Citations

Jan 1, 1989·Immunogenetics·R Wank, H Grosse-Wilde
Jan 1, 1986·Tissue Antigens·M J JagerJ J van Rood
Jan 1, 1982·Immunological Reviews·A TermijtelenJ J van Rood
Aug 5, 1982·Nature·A van LeeuwenJ J van Rood
May 1, 1983·Tissue Antigens·A TermijtelenJ J van Rood
Oct 1, 1988·Journal of Immunogenetics·C FarrellC Hoadley
Mar 1, 1984·Scandinavian Journal of Immunology·A TermijtelenJ J van Rood

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