The role of prophylactic antibiotics in spinal instrumentation. A rabbit model

Spine
J P GuibouxH N Herkowitz

Abstract

A rabbit model was used to test the efficacy of cefazolin administered in various therapeutic regimens in preventing iatrogenic Staphylococcus aureus infections during spinal instrumentation. To assess the efficacy of various prophylactic therapeutic regimens of cefazolin in preventing iatrogenic S. aureus infections during spinal instrumentation. Previous studies have not dealt specifically with the occurrence of iatrogenic S. aureus infections during spinal instrumentation in a prospective fashion. Twenty New Zealand White rabbits underwent a posterior approach to the lumbar spine. Fifteen of the animals then had double-braided 26-gauge surgical wire placed around bilateral L3-L4 and L4-L5 facet joints. A standardized volume of a 103 S. aureus/mL of solution was then inoculated onto the fusion-hardware site in all rabbits. The rabbits were divided into four groups receiving various antibiotic dose regimens. Five days after surgery, the animals were killed, and cultures were obtained. All of the rabbits receiving no antibiotic had fusion sites infected with S. aureus. None of the animals who received prophylactic cefazolin produced cultures that grew S. aureus. A specimen from one fusion site cultured Staphylococcus epidermidi...Continue Reading

Citations

Oct 18, 2000·Journal of Biomedical Materials Research·M W NijhofA J Verbout
May 25, 2007·Archives of Orthopaedic and Trauma Surgery·Ender Ali OfluogluHalil Toplamaoglu
Jul 2, 2015·Frontiers in Medicine·A I StavrakisN M Bernthal
Apr 27, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eric M DworskyNicholas M Bernthal
Apr 15, 2004·Spine·Erwin M BrownUNKNOWN British Society for Antimicrobial Chemotherapy Working Party on Neurosurgical Infections
Jun 27, 2020·Disease Models & Mechanisms·Oren GordonSanjay K Jain
Jan 3, 2014·The Journal of Bone and Joint Surgery. American Volume·Lukas P ZebalaK Daniel Riew

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.