Apr 19, 1984

The role of protein kinase C in cell surface signal transduction and tumour promotion

Nature
Y Nishizuka

Abstract

Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. When cells are stimulated, protein kinase C is transiently activated by diacylglycerol which is produced in the membrane during the signal-induced turnover of inositol phospholipids. Tumour-promoting phorbol esters, when intercalated into the cell membrane, may substitute for diacylglycerol and permanently activate protein kinase C. The enzyme probably serves as a receptor for the tumour promoters. Further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.

Mentioned in this Paper

C1S
Tumor Promoters
Phosphatidylinositols
Calcium
Neoplasms
Tumor Lysis Syndrome
Promoter
Cell Surface
Protein KINASE
Phospholipids

About this Paper

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