The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.

Immunology
Philippe PouliotMartin Olivier

Abstract

Protein tyrosine phosphorylation is an important early event in the signal transduction of numerous cell receptors involved in the immune response. The implication of protein tyrosine kinases in allergic asthma is well recognized, but the role of protein tyrosine phosphatases (PTPs) remains poorly understood. However, we recently reported that global inhibition of PTPs during either the allergen-sensitization phase or the allergen-challenge phase reduced the development of asthma and that this correlated with an increased T helper 1 (Th1) response in both lung and spleen tissues. Therefore, in this study we investigated individual roles of PTPs involved in regulating the immune response. We observed that genetic deficiency for PTP-1B resulted in increased recruitment of lung inflammatory cells, while protein tyrosine phosphatase-phosphatase and tensin homologue deleted (PTP-PEST)-deficient mice exhibited a phenotype similar to that of wild-type mice. Importantly, we found that a heterozygous mutation of T cell PTP (TC-PTP) dramatically abrogates immunoglobulin E production and reduces the recruitment of inflammatory cells to the lung, conferring an important role for TC-PTP in the development of allergic asthma. As opposed to o...Continue Reading

References

Aug 29, 1997·The Journal of Experimental Medicine·K E You-TenM L Tremblay
Apr 16, 1998·Current Biology : CB·F LiuJ Chernoff
Jun 8, 1999·Annual Review of Immunology·M Wills-Karp
Aug 24, 1999·European Journal of Immunology·J BrockdorffT Mustelin
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z H XieR P Siraganian
Mar 29, 2000·Biochemical and Biophysical Research Communications·K KumanoI Iwamoto
Jul 13, 2000·Cellular Signalling·J M ElleryP J Nicholls
Sep 21, 2000·Seminars in Immunology·J ZhangK A Siminovitch
Jul 12, 2001·The Journal of Allergy and Clinical Immunology·G T De SanctisA Daser
Nov 6, 2001·The Journal of Biological Chemistry·M P MyersN K Tonks
Feb 22, 2002·European Journal of Biochemistry·Alan ChengMichel L Tremblay
Mar 23, 2002·Current Biology : CB·Paul D SimoncicC Jane McGlade
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Wei DuanW S Fred Wong
Jan 4, 2003·The Journal of Clinical Investigation·Tohru KamataToshinori Nakayama
Apr 3, 2003·The Journal of Clinical Investigation·Yong-Geun KwakYong C Lee
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neely E KilgoreBrian D Evavold
May 16, 2003·Molecular and Cellular Biology·Feng GuYves R Boisclair
Nov 25, 2003·Current Opinion in Immunology·Reuben P Siraganian
Jun 10, 2004·Cell·Andres AlonsoTomas Mustelin
Oct 9, 2004·The Journal of Biological Chemistry·Maritza JaramilloMartin Olivier
Jan 5, 2005·Nature Reviews. Immunology·Tomas MustelinNunzio Bottini
Sep 30, 2005·American Journal of Respiratory and Critical Care Medicine·Shigeki MatsubaraErwin W Gelfand
Feb 14, 2006·European Journal of Pharmacology·Ian M AdcockKazuhiro Ito
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Krista M HeinonenMichel L Tremblay
Apr 18, 2006·Nature Medicine·Marie-Julie DuboisAndré Marette
Sep 26, 2006·Canadian Journal of Physiology and Pharmacology·Paul D SimoncicMichel L Tremblay
Feb 16, 2008·American Journal of Respiratory Cell and Molecular Biology·Alessandra Rinna, Henry Jay Forman
Apr 3, 2008·European Journal of Immunology·David J GregoryMartin Olivier
Oct 28, 2008·American Journal of Respiratory Cell and Molecular Biology·Sun Young OhZhou Zhu
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe PouliotMartin Olivier

❮ Previous
Next ❯

Citations

May 21, 2013·Analytical Chemistry·Ryan M PhillipsNancy L Allbritton
May 31, 2018·American Journal of Respiratory Cell and Molecular Biology·Yael Aschner, Gregory P Downey
Nov 1, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Masanobu SuzukiAkihiro Homma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.