The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery

Medicinal Chemistry
Simone Q PantaleaoKathia M Honorio

Abstract

Due to the increasing number of diabetes cases worldwide, there is an international concern to provide even more effective treatments to control this condition. This review brings together a selection of studies that helped to broaden the comprehension of various biological targets and associated mechanisms involved in type 2 diabetes mellitus. Such studies demonstrated that QSAR techniques and virtual screenings have been successfully employed in drug design projects. Therefore, the main goal of this review is to give the state-of-art for the development of new drugs for the treatment of type 2 diabetes mellitus and to evaluate how computational tools, such as virtual screening and 3D-QSAR, can aid the development of new drugs with reduced adverse side effects.

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