The role of quetiapine in the treatment of bipolar disorder

Expert Opinion on Pharmacotherapy
Stefano PiniGiovanni B Cassano

Abstract

Through a review of randomised, controlled trials, this article evaluates the efficacy and tolerability of quetiapine in the acute and maintenance phases of bipolar disorder. In trials involving mania patients, quetiapine was found to be effective as adjunctive therapy in combination with lithium or valproate, significantly superior to placebo, and equal to lithium or haloperidol as monotherapy. With regard to the prevention of relapses in bipolar disorder, quetiapine seems to differ from other atypical antipsychotics in its characteristics as a mood stabiliser, which are associated with a promising efficacy in the treatment of bipolar depressive episodes. However, further larger controlled long-term prospective studies are needed to confirm the efficacy of quetiapine for the prevention of relapses in bipolar disorder. Quetiapine seems to have a satisfactory safety and tolerability profile, with a low prevalence of extrapyramidal symptom-related adverse events, treatment-emergent depression and weight gain. Sedation is the main side effect of treatment with quetiapine.

References

Apr 1, 1986·Archives of General Psychiatry·S MukherjeeS Shukla
Feb 1, 1988·Psychological Medicine·M M WeissmanL P Florio
May 1, 1995·The American Journal of Drug and Alcohol Abuse·D A D'MelloB Msibi
Jan 1, 1993·Psychopharmacology·C F Saller, A I Salama
Mar 1, 1997·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S N GhaemiC J Truman
May 1, 1997·Psychoneuroendocrinology·N E Goeders
Sep 23, 1997·Psychological Medicine·R C KesslerS Zhao
Jan 20, 1998·The American Journal of Psychiatry·M P Freeman, A L Stoll
Mar 10, 1998·The Journal of Clinical Psychiatry·C A ZarateA Madrid
Mar 13, 1999·The Journal of Clinical Psychiatry·M S BauerB J Powell
Apr 8, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D G DanielM Lakshminarayanan
Aug 10, 1999·Journal of Clinical Psychopharmacology·S N Ghaemi, F K Goodwin
Jan 11, 2000·Journal of Affective Disorders·D K WhitneyK Kueneman
Feb 7, 2001·Journal of Geriatric Psychiatry and Neurology·S MadhusoodananA Alcantra
May 19, 2000·The Journal of Clinical Psychiatry·C A ZarateJ Zapatel
Jun 1, 2000·The American Journal of Psychiatry·A I GreenA F Schatzberg
Jul 13, 2000·Drug and Alcohol Dependence·C K FarrenT R Kosten
Jul 27, 2000·The American Journal of Psychiatry·E Dunayevich, S M Strakowski
Oct 6, 2000·Biological Psychiatry·S M StrakowskiS Arndt
Oct 26, 2000·Clinical Therapeutics·P N TariotI W Rak
May 18, 2001·Journal of Affective Disorders·E Sherwood BrownN Rajan Thomas
Jul 24, 2001·Bipolar Disorders·S N Ghaemi
Oct 30, 2001·The Journal of Clinical Psychiatry·M SajatovicC R Bingham
Nov 1, 2001·Journal of Cardiothoracic and Vascular Anesthesia·T A Alston
Feb 28, 2002·Psychological Medicine·Frederick Cassidy, Bernard J Carroll
Mar 1, 2002·Journal of Affective Disorders·G S LeverichR M Post
Mar 5, 2002·The Journal of Clinical Psychiatry·Michael E Thase
Oct 5, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Melissa P DelbelloStephen M Strakowski
Dec 14, 2002·Bipolar Disorders·Eduard VietaCarla Torrent
Jan 10, 2003·Bipolar Disorders·E Sherwood BrownLeonardo Bobadilla
Jan 14, 2003·The Journal of Clinical Psychiatry·Martha SajatovicDennis E Sweitzer
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kenneth N Sokolski, Thomas F Denson
Oct 9, 2003·Human Psychopharmacology·Paolo StrattaAlessandro Rossi
Apr 27, 2004·International Clinical Psychopharmacology·T SuppesR M Post
Nov 9, 2004·Clinical Pharmacokinetics·George E JaskiwChiao Yeh
Nov 13, 2004·Journal of Clinical Psychopharmacology·Lakshmi N YathamAnd Mårten Vågerö
Jan 25, 2005·Drugs & Aging·Martha SajatovicNicoleta Coconcea

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Citations

Jul 28, 2010·Clinical Neuropharmacology·Jochen MutschlerMartin Grosshans
Oct 1, 2007·Expert Review of Pharmacoeconomics & Outcomes Research·Rogier M KlokMaarten J Postma
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ioannis MichopoulosLefteris Lykouras
Nov 11, 2006·International Journal of Geriatric Psychiatry·Lorenz HilwerlingStefan Georg Schröder
Dec 5, 2006·Current Opinion in Psychiatry·Marek Jarema
Jan 1, 2008·International Journal of Psychiatry in Clinical Practice·Stanley Victor CattsJames Scott

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