The Role of Radiation Oncology in Immuno-Oncology

The Oncologist
Xiangjiao MengJinming Yu

Abstract

Despite the promising efficacy of immunotherapy in some patients, many other patients are resistant. The synergistic effect of radiotherapy (RT) in combination with immunotherapy reported in case reports and clinical trials has piqued the interest of radiologists in investigating the underlying mechanisms and efficacy of the combination in preclinical and clinical trials. To date, the reported data are limited to small-sized samples, trials lacking a comparison arm, and trials using diverse immunotherapies, various radiation doses, and fractionations. There are just a few studies comparing the efficacy of immunotherapy and radiotherapy to that of conventional therapies or different combinations. Radiologists should design and conduct clinical trials wisely to confirm the efficacy of the combination, particularly the abscopal effect, identify the best combination of various immunotherapeutic drugs and different radiation models for patients, identify the best sequence of the combination, determine the optimal timing of the combination, select the target site and volume, lower adverse effects, and explore predictive models to identify patients who may benefit from the combination therapy. We expect that these clinical trials perf...Continue Reading

References

Oct 1, 1975·The British Journal of Radiology·D P Kingsley
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Aug 27, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Zahidunnabi DewanSandra Demaria
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joshua D BrodyRonald Levy
Sep 10, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Xue MengJinming Yu
Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
Nov 1, 2012·Frontiers in Oncology·Sandra Demaria, Silvia C Formenti
Jan 17, 2013·Translational Oncology·Susan M HinikerSusan J Knox
Jan 3, 2014·The Journal of Clinical Investigation·Liufu DengYang-Xin Fu
Jan 10, 2014·Cancer Medicine·Ann W SilkChristopher D Lao
Apr 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander FilatenkovSamuel Strober
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hui ZhangShuanghu Yuan
Dec 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K A AhmedG T Gibney
Mar 10, 2016·Nature Reviews. Clinical Oncology·Michael B BernsteinJoe Y Chang
Aug 30, 2016·CA: a Cancer Journal for Clinicians·Fernanda G HerreraGeorge Coukos
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chad TangDavid S Hong
Sep 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Susan M HinikerSusan J Knox
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Oct 16, 2016·Journal of Immunotherapy·Jéssica Ribeiro GomesAntônio C Buzaid
Oct 21, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonin LevyEric Deutsch
Dec 17, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aaron T MayerSanjiv S Gambhir
Jan 18, 2017·Nature Reviews. Clinical Oncology·Ralph R WeichselbaumYang-Xin Fu
Mar 6, 2017·Critical Reviews in Oncology/hematology·Enrique ChajonRenaud De Crevoisier
Apr 7, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R ShibakiN Yamamoto
Apr 12, 2017·Nature·Alexander C HuangE John Wherry
Aug 18, 2017·International Journal of Radiation Oncology, Biology, Physics·Noelle L WilliamsWenyin Shi

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Citations

May 30, 2020·Cell Research·Yonina R Murciano-GoroffJedd D Wolchok
Aug 28, 2020·Expert Review of Anticancer Therapy·Saharnaz PezeshkiNima Rezaei
Apr 11, 2020·International Journal of Molecular Sciences·Achamaporn PunnanitinontSantosh K Patnaik
Aug 14, 2021·Clinical & Experimental Metastasis·Baldassarre Stea, Russell S Witte

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Clinical Trials Mentioned

NCT01176461
NCT01176474
NCT02663440
NCT02946138
NCT03113851
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