The role of radiography and MRI for eligibility assessment in DMOAD trials of knee OA

Nature Reviews. Rheumatology
Frank W RoemerAli Guermazi

Abstract

Currently, no disease-modifying osteoarthritis drugs (DMOADs) have been approved. Past clinical trials have failed for several reasons, including the commonly applied definition of eligibility based on radiographic assessment of joint structure. In the context of precision medicine, finding the appropriate patient for a specific treatment approach will be of increasing relevance. Phenotypic stratification by use of imaging at the time of determining eligibility for clinical trials will be paramount and cannot be achieved using radiography alone. Furthermore, identification of joints at high risk of rapid progression of osteoarthritis is needed in order to enable a more efficient DMOAD trial design. In addition, joints at high risk of collapse need to be excluded at screening. The use of MRI might offer advantages over radiography in this context. Technological advances and simplified image assessment address many of the commonly perceived barriers to the application of MRI to assessment of eligibility for DMOAD clinical trials.

References

Jul 29, 1999·Skeletal Radiology·S EharaM Abe
Jun 20, 2000·The Journal of Bone and Joint Surgery. American Volume·T Yamamoto, P G Bullough
Apr 3, 2001·Annals of Internal Medicine·D T FelsonD R Gale
Sep 11, 2003·Annals of Internal Medicine·David T FelsonDaniel Gale
Dec 1, 1957·Annals of the Rheumatic Diseases·J H KELLGREN, J S LAWRENCE
Feb 20, 2004·Osteoarthritis and Cartilage·C G PeterfyH K Genant
Nov 1, 2005·Arthritis and Rheumatism·Kenneth D Brandt, Steven A Mazzuca
May 23, 2006·Radiology·Peter R KornaatMargreet Kloppenburg
Mar 25, 2008·European Journal of Radiology·S L J JamesA M Davies
Sep 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Robert AllaireChristopher D Harner
Jul 28, 2009·Radiologic Clinics of North America·Patrick OmoumiBruno C Vande Berg
May 18, 2010·Annals of the Rheumatic Diseases·K BakerD T Felson
Aug 24, 2010·Climacteric : the Journal of the International Menopause Society·P AlexandersenC Christiansen
Sep 11, 2010·Annals of the Rheumatic Diseases·Erlangga YusufMargreet Kloppenburg
Jun 21, 2011·Lancet·Johannes W J BijlsmaFloris P J G Lafeber
Jul 23, 2011·Radiology·Frank W RoemerAli Guermazi
Mar 24, 2012·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Sarah HenryChristopher D Harner
May 23, 2012·Nature Reviews. Rheumatology·Martin EnglundAli Guermazi
Sep 14, 2012·The American Journal of Sports Medicine·Carl K SchillhammerJohn P Cannizzaro
Dec 6, 2012·Seminars in Musculoskeletal Radiology·Daichi HayashiFrank W Roemer
Jan 8, 2013·Seminars in Arthritis and Rheumatism·Marie-Pierre Hellio Le GraverandEric Vignon
May 31, 2013·Rheumatic Diseases Clinics of North America·Ali GuermaziDavid T Felson
Nov 13, 2013·Osteoarthritis and Cartilage·M A KarsdalA C Bay-Jensen

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Citations

May 20, 2020·Radiology·Frank W RoemerAli Guermazi
Jun 16, 2019·Nature Reviews. Rheumatology·Carolyn A EmeryNigel K Arden
Nov 13, 2018·Expert Opinion on Emerging Drugs·Win Min OoDavid John Hunter
Sep 26, 2020·Therapeutic Advances in Musculoskeletal Disease·Jorge A Roman-BlasGabriel Herrero-Beaumont
Jan 21, 2021·Journal of Orthopaedic Surgery and Research·Zhenxing SiJinglong Yan
Apr 4, 2021·International Journal of Molecular Sciences·Elena RezuşCiprian Rezuş
Sep 2, 2021·Nature Reviews. Rheumatology·Armaghan MahmoudianFrank P Luyten
Sep 22, 2021·Seminars in Musculoskeletal Radiology·Edwin H G OeiRianne A van der Heijden

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