The role of radiotherapy in locally advanced pancreatic carcinoma.

Nature Reviews. Gastroenterology & Hepatology
Ruchika GuttRalph R Weichselbaum

Abstract

The prognosis for locally advanced pancreatic carcinoma remains dismal despite advances in chemotherapy and radiotherapy over the past few decades. The use of radiotherapy for pancreatic carcinoma is often disputed because of the hypothesis that patients with pancreatic cancer die from distant metastases. It is well accepted that the greatest chance for cure of pancreatic cancer involves surgical resection of the primary tumor. However, there is much controversy about the role of radiotherapy in local disease control. The aim of this Review is to discuss data from the available studies, both prospective and retrospective, that evaluate treatment options for locally advanced pancreatic cancer. We focus on the benefits associated with local therapies, including radiotherapy and surgical resection, as they relate to improved local disease control, prolonged overall survival and improved symptom control.

References

Jan 1, 1988·Journal of Pain and Symptom Management·B D MinskyZ Fuks
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M MohiuddinR Cantor
Nov 1, 1995·Pancreas·T KamisawaA Okamoto
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Jun 19, 1998·Journal of the American College of Surgeons·H FriessM W Büchler
Nov 20, 1998·Frontiers in Bioscience : a Journal and Virtual Library·C G Willett, A L Warshaw
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·J W WongA A Martinez
May 2, 2001·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J F PingpankB L Eisenberg
Jun 8, 2001·International Journal of Radiation Oncology, Biology, Physics·M ReniV Di Carlo
Nov 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J McGinnT S Lawrence
Apr 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Christopher H CraneN A Janjan
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Hiroyuki ShinchiTakashi Aikou
Oct 26, 2002·Current Problems in Cancer·Theresa Pluth YeoCharles J Yeo
Jan 24, 2003·International Journal of Gastrointestinal Cancer·C H CraneR A Wolff
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Chung-Pin LiSang-Hue Yen
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Floris M WachtersHarm H Kampinga
Sep 18, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·John B AmmoriCornelius J McGinn
Sep 25, 2003·Seminars in Oncology·Daniel G Haller
Oct 2, 2003·Nature·Sarah P ThayerMatthias Hebrok
Jan 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil SenzerNader Hanna
May 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Michael T MilanoRuth Heimann
Jul 28, 2004·International Journal of Radiation Oncology, Biology, Physics·Aaron M AllenCornelius J McGinn
Sep 14, 2004·International Journal of Gastrointestinal Cancer·Aaron R SassonBurton L Eisenberg
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LouvetUNKNOWN GISCAD
Jul 2, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Morten HoyerHans von der Maase
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettDavid P Ryan
Oct 21, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D StefanidisC R Thomas

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Citations

Jun 30, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christine A Iacobuzio-Donahue
Apr 15, 2014·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Camille E NoelParag J Parikh
Dec 18, 2013·Current Problems in Cancer·Eun Ji Shin, Mouen Khashab
Mar 16, 2013·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Peter V DraganovMihir S Wagh
Dec 29, 2013·Journal of Experimental & Clinical Cancer Research : CR·Hao WangYang Gao
Jan 6, 2016·World Journal of Gastroenterology : WJG·Stephen Y OhVincent J Picozzi
Nov 11, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Song GaoLuming Liu
Mar 28, 2021·Seminars in Oncology·Elizabeth J BussDavid P Horowitz

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