The role of receptor for advanced glycation end products in airway inflammation in CF and CF related diabetes

Scientific Reports
Siobhain MulrennanPhilip J Thompson

Abstract

Cystic Fibrosis (CF) is often accompanied by diabetes leading to worsening lung function, the reason for which is unclear. The receptor for advanced-glycation-end-products (RAGE) regulates immune responses and inflammation and has been linked to diabetes and possibly CF. We performed a pilot study to determine if CF and CF-related diabetes (CFRD) are associated with enhanced RAGE expression. Full length (fl)RAGE, soluble (s)RAGE, endogenous soluble (es)RAGE, S100A12 (enRAGE) and advanced-glycation-end-products (AGE) expression was assessed in serum, white blood cells and sputum of patients with CF; diabetes; CFRD and healthy subjects. Sputum enRAGE/sRAGE ratios were high in CF but particularly in CFRD which negatively correlated with % predicted FEV1. Serum AGE and AGE/sRAGE ratios were high in diabetics but not in CF. A complex, multifaceted approach was used to assess the role of RAGE and its ligands which is fundamental to determining their impact on airway inflammation. There is a clear association between RAGE activity in the airways of CF and CFRD patients that is not evident in the vascular compartment and correlates with lung function, in contrast to diabetes. This strongly suggests a role for RAGE in contributing to th...Continue Reading

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Citations

Jan 29, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·William R HuntJason M Hansen
Mar 20, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D H LimoliJ B Goldberg
Oct 16, 2016·Canadian Journal of Diabetes·Valérie BoudreauRémi Rabasa-Lhoret
Mar 5, 2016·Scientific Reports·Michaele B ManigrassoAnn Marie Schmidt
Jun 5, 2019·International Forum of Allergy & Rhinology·Anna C ZemkeStella E Lee
Aug 1, 2020·The European Respiratory Journal·Charles D BengtsonMatthias Salathe
Aug 3, 2020·Life Sciences·Gerwyn MorrisMichael Berk
Feb 19, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Bernadette J PrenticeJohn Widger
Feb 26, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Priyamvada S ChukowryAlice M Turner
Jul 31, 2021·World Journal of Diabetes·Rebeca Viurcos-Sanabria, Galileo Escobedo

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