The role of red blood cell deformability and Na,K-ATPase function in selected risk factors of cardiovascular diseases in humans: focus on hypertension, diabetes mellitus and hypercholesterolemia
Deformability of red blood cells (RBC) is the ability of RBC to change their shape in order to pass through narrow capillaries in circulation. Deterioration in deformability of RBC contributes to alterations in microcirculatory blood flow and delivery of oxygen to tissues. Several factors are responsible for maintenance of RBC deformability. One of them is the Na,K-ATPase known as crucial enzyme in maintenance of intracellular ionic homeostasis affecting thus regulation of cellular volume and consequently RBC deformability. Decreased deformability of RBC has been found to be the marker of adverse outcomes in cardiovascular diseases (CVD) and the presence of cardiovascular risk factors influences rheological properties of the blood. This review summarizes knowledge concerning the RBC deformability in connection with selected risk factors of CVD, including hypertension, hyperlipidemia, and diabetes mellitus, based exclusively on papers from human studies. We attempted to provide an update on important issues regarding the role of Na,K-ATPase in RBC deformability. In patients suffering from hypertension as well as diabetes mellitus the Na,K-ATPase appears to be responsible for the changes leading to alterations in RBC deformabilit...Continue Reading
An adverse effect of insulin on the oxygen-release capacity of red blood cells in nonacidotic diabetics
Modification of red cell membrane structure by cholesterol-rich lipid dispersions. A model for the primary spur cell defect
Erythrocyte Na-K-ATPase membrane activity in obese patients fed over a long-term period with a very-low-calorie diet
Membrane abnormality of erythrocytes is highly dependent on salt intake and renin profile in essential hypertension: an electron spin resonance study
Infusion of synthetic human C-peptide does not affect plasma glucose, serum insulin, or plasma glucagon in healthy subjects
Correction by insulin added in vitro of abnormal membrane fluidity of the erythrocytes from type 1 (insulin-dependent) diabetic patients
The biological and immunological properties of pork and beef insulin, proinsulin, and connecting peptides
Improvement of erythrocyte deformability by cholesterol-lowering therapy with pravastatin in hypercholesterolemic patients
The effect of human proinsulin C-peptide on erythrocyte deformability in patients with Type I diabetes mellitus
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation
Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na(+) + K(+))- and Ca(++)-ATPase activities in high glucose-treated human erythrocytes
Effects of direct adsorption of lipoproteins apheresis on lipoproteins, low-density lipoprotein subtypes, and hemorheology in hypercholesterolemic patients with coronary artery disease
The effect of atorvastatin on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia
Effects of simvastatin and pravastatin on peroxidation of erythrocyte plasma membrane lipids in patients with type 2 hypercholesterolemia
Hormone replacement therapy improves membrane fluidity of erythrocytes in postmenopausal women: an electron paramagnetic resonance investigation
Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia
Short-term effect of low-dose atorvastatin on haemorrheological parameters, platelet aggregation and endothelial function in patients with cerebrovascular disease and hyperlipidaemia
Erythrocyte membrane alterations during ageing affect beta-D-glucuronidase and neutral sialidase in elderly healthy subjects
The beneficial effects of lipid-lowering drugs beyond lipid-lowering effects: a comparative study with pravastatin, atorvastatin, and fenofibrate in patients with type IIa and type IIb hyperlipidemia
C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients.
Long-term LDL apheresis does not stably improve hemorheology in hypercholesterolemic patients with coronary artery disease
Left ventricular geometry and rheological properties of erythrocytes in patients at cardiovascular disease risk
Pioglitazone in addition to metformin improves erythrocyte deformability in patients with Type 2 diabetes mellitus
Chronic cigarette smoking alters erythrocyte membrane lipid composition and properties in male human volunteers
Evolution of rheological properties of erythrocytes and left ventricular geometry in cardiovascular disease risk patients
Roles of adiponectin and oxidative stress in the regulation of membrane microviscosity of red blood cells in hypertensive men-an electron spin resonance study
3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells.
Erythrocyte deformability in children with autism spectrum disorder: correlation with clinical features
The potential role of Na-K-ATPase and its signaling in the development of anemia in chronic kidney disease.
Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes.
Diet-Dependent and Diet-Independent Hemorheological Alterations in Celiac Disease: A Case-Control Study.
High-dose nitroglycerin administered during rewarming preserves erythrocyte deformability in cardiac surgery with cardiopulmonary bypass.
Altered red blood cell deformability-A novel hypothesis for retinal microangiopathy in diabetic retinopathy.
Serum lipoprotein and RBC rigidity index to predict cerebral infarction in patients with carotid artery stenosis
Mechanisms Modified by (-)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies.
Ultra-Small Superparamagnetic Iron-Oxide Nanoparticles Exert Different Effects on Erythrocytes in Normotensive and Hypertensive Rats.
Modulatory Effect of Chaetomorpha gracilis on Erythrocytes Functions and Metabolic Disorders in Mice Fed a High-cholesterol Diet.
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