The role of regenerative cell proliferation in chloroform-induced cancer

Toxicology Letters
B E ButterworthD C Wolf

Abstract

Chloroform produces cancer by a nongenotoxic-cytotoxic mode of action, with no increased cancer risk expected at noncytotoxic doses. The default risk assessment for inhaled chloroform relies on liver tumor incidence from a gavage study with female B6C3F1 mice and estimates a virtually safe dose (VSD) at an airborne concentration of 0.000008 ppm of chloroform. In contrast, a 1000-fold safety factor applied to the NOAEL for liver cytotoxicity from inhalation studies yields a VSD of 0.01 ppm. This estimate relies on inhalation data and is more consistent with the mode of action of chloroform.

References

Aug 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T A JorgensonM Robinson
Jan 1, 1982·Environmental Mutagenesis·J C MirsalisB E Butterworth
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J L LarsonB E Butterworth
Apr 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J L LarsonB E Butterworth
Jan 1, 1994·Environmental and Molecular Mutagenesis·J L LarsonB E Butterworth
Apr 1, 1993·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J L LarsonB E Butterworth

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Citations

Sep 24, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Glenda J MoserRobert Maronpot
May 2, 2015·Regulatory Toxicology and Pharmacology : RTP·Christopher J BorgertRichard A Becker
Sep 26, 2007·Free Radical Biology & Medicine·Nilesh W GaikwadErcole L Cavalieri
Oct 27, 2009·Critical Reviews in Toxicology·David J JollowLawrence C Mohr

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