PMID: 6991605Apr 1, 1980Paper

The role of regional differences in the major histocompatibility complex in the production during pregnancy of a serum factor inhibiting macrophage migration

Journal of Immunogenetics
T J Gill, H W Kunz

Abstract

The response by the mother to the paternal antigens of her foetus was evaluated in the rat by the production of a serum factor which inhibits macrophage migration (serum inhibitory factor, SIF). The SIF response depended upon antigenic differences controlled by genes within the major histocompatibility complex (MHC), as demonstrated by the use of congenic strains. Differences between mother and foetus within the RT1.A region of the MHC led to SIF stimulation, whereas, differences in the RT1.B region did not. The SIF response followed the course of the pregnancy: it began at the time of implantation, reached a maximum at birth and then fell precipitously. In contrast, the SIF response to skin grafting did not correlate with differences in the MHC. Thus, the antigenic factors stimulating this maternal response to foetal antigens appear to depend upon a unique type of genetic difference, and this may be a factor in the apparent immunologic privilege enjoyed by the foetus during gestation.

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Citations

Aug 30, 2011·FEBS Letters·Daisuke NakayamaSoichi Takeda
Jun 2, 2012·Journal of Thrombosis and Haemostasis : JTH·H C HemkerR M W Kremers
Aug 1, 2019·Journal of Thrombosis and Haemostasis : JTH·Magdalena GierulaJosefin Ahnström
Nov 26, 2014·Journal of Thrombosis and Haemostasis : JTH·R M W KremersH C Hemker
Apr 18, 2009·Blood·Paola E J van der MeijdenJohan W M Heemskerk
Oct 24, 2002·Blood·Kenneth G Mann, Michael Kalafatis
Nov 15, 2013·Blood·Gerry A F NicolaesBruno O Villoutreix
Aug 23, 2002·Protein Science : a Publication of the Protein Society·Andrew J GaleJohn H Griffin
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·P G LindqvistA Hillarp
Jun 23, 2004·European Journal of Biochemistry·Gerry A F NicolaesBruno O Villoutreix
Jan 27, 2006·Proteins·Ludovic AutinBruno O Villoutreix
May 30, 2009·The FEBS Journal·Tomotaka HaradaKeiji Hasumi
Oct 24, 2007·Journal of Thrombosis and Haemostasis : JTH·S Stoilova-McPhieG A F Nicolaes
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·A W F T TooriansJ Rosing
Jun 19, 2013·The Journal of Biological Chemistry·Nicola PozziEnrico Di Cera
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·X L Zheng
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·S Krishnaswamy
Nov 2, 2013·The Journal of Biological Chemistry·Sergio Barranco-MedinaEnrico Di Cera
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Jul 24, 2020·Journal of Thrombosis and Haemostasis : JTH·Magdalena Gierula, Josefin Ahnström
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May 11, 2016·International Journal of Laboratory Hematology·Björn Dahlbäck
Apr 13, 2017·Frontiers in Microbiology·Monica L VieiraAna Lucia T O Nascimento

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