The Role of Renal Progenitors in Renal Regeneration

Nephron
Catherine Meyer-Schwesinger

Abstract

The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.

Citations

Feb 7, 2016·Seminars in Cell & Developmental Biology·Soeren S Lienkamp
Jun 5, 2014·Kidney International·Paola Romagnani, Benjamin D Humphreys
Feb 16, 2018·Journal of the American Society of Nephrology : JASN·Ina Maria SchiesslHayo Castrop
May 30, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Teresa LorenziManrico Morroni
Nov 3, 2016·Current Opinion in Organ Transplantation·Oded Volovelsky, Raphael Kopan
Dec 19, 2019·International Journal of Molecular Sciences·Nadezda V AndrianovaDmitry B Zorov
Nov 26, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Aoran HuangLi Yao
Jul 10, 2017·Kidney International·Linda HickmannVladimir T Todorov

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