Abstract
Renal sympathetic efferent and afferent nerves, which lie within and immediately adjacent to the wall of the renal artery, contribute to the pathogenesis of hypertension. Because the causative factors of hypertension change over time, denervation of both efferent and afferent nerves should result in long-term attenuation of the hypertension. The importance of the renal nerves in patients with hypertension can now be defined with the novel development of percutaneous minimally invasive renal denervation from within the renal artery using radiofrequency energy as a therapeutic strategy. Studies thus far show that catheter-based renal denervation in patients with refractory hypertension lowers systolic blood pressure 27 mm Hg by 12 months with estimated glomerular filtration rate remaining stable. An attenuation of hypertension of this magnitude by catheter-based renal sympathetic denervation in combination with pharmacologic therapy is likely to be valuable in decreasing the risks of stroke, left ventricular hypertrophy, heart failure, and chronic renal failure.
References
Nov 1, 1977·Circulation·A S Zanchetti
Apr 1, 1976·The Journal of Clinical Investigation·E Bell-ReussC W Gottschalk
Sep 1, 1989·Klinische Wochenschrift·H KirchheimP Persson
Dec 1, 1987·Artificial Organs·G F DiBona
Aug 1, 1984·Journal of Hypertension·R E KatholiW T Woods
Mar 1, 1983·Hypertension·R E KatholiW T Woods
Sep 1, 1981·British Journal of Pharmacology·D S McQueen, J A Ribeiro
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V M CampeseM Koss
Apr 1, 1995·Radiology·R E KatholiC L Lucore
Feb 22, 2002·Current Opinion in Nephrology and Hypertension·Gerald F DiBona
Oct 9, 2002·Circulation·Martin HausbergKarl Heinz Rahn
Mar 8, 2003·Hypertension·Gerald F DiBona
Feb 26, 2004·Hypertension·Jaap A Joles, Hein A Koomans
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
May 16, 2007·Hypertension·Harold D SchultzYanfeng Ding
Sep 10, 2008·Hypertension·Guido GrassiGiuseppe Mancia
Sep 19, 2008·Journal of the American Society of Nephrology : JASN·Markus P SchlaichGavin W Lambert
Apr 1, 2009·Lancet·Michael Doumas, Stella Douma
Citations
Feb 11, 2011·Current Hypertension Reports·Alan H Gradman
Mar 27, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuko MasuoMarkus P Schlaich
Dec 15, 2010·Journal of Applied Physiology·L Gabriel Navar
Dec 15, 2010·Journal of Applied Physiology·Hiroyuki KoboriRuy R Campos
Oct 1, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Dirk ProchnauRalf Surber
Apr 1, 2014·Clinical and Experimental Hypertension : CHE·Alluru S Reddi
Jun 19, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Malini MadhavanSamuel J Asirvatham
Jan 4, 2013·The Journal of Clinical Hypertension·Priyanka GosainRajender Agarwal
Nov 1, 2011·British Journal of Pharmacology·B Zogovic, P M Pilowsky
Dec 27, 2013·International Journal of Hypertension·Y Castro Torres, Richard E Katholi
Oct 29, 2014·International Journal of Hypertension·Sonia Alves GouveaGláucia R Abreu
Jul 21, 2012·JACC. Cardiovascular Interventions·Edward D Frohlich
Jan 21, 2014·JACC. Cardiovascular Interventions·Stefano F RimoldiYves Allemann
Jun 19, 2010·American Journal of Hypertension·Noreen F Rossi
Jan 10, 2014·Angiology·Thomas D GossiosHaralambos Karvounis
Aug 3, 2017·International Journal of Molecular Sciences·Jasdeep KaurPaul J Fadel
May 27, 2010·Journal of Hypertension·Alain G Dupont, Sofie Brouwers
Jul 22, 2014·The Journal of Clinical Hypertension·Zhi-Hui ZhangXiao-Yan Wang
Feb 23, 2021·Heart, Lung & Circulation·Travis Chong, Michael Nguyen
Dec 29, 2010·Journal of Applied Physiology·Di Zhao
Nov 18, 2009·Progress in Cardiovascular Diseases·Vincent J Canzanello, Vesna D Garovic