The role of repair in radiobiology

Experientia
T ALPER, W A Cramp

Abstract

Apart from cancer and mutation induction, radiobiological effects on mammals are mostly attributable to cell 'death', defined as loss of proliferative capacity. Survival curves relate retention of that capacity to radiation dose, and often manifest a quasi-threshold ('shoulder'). The shoulder is attributable to an initial mechanism of repair ('Q-repair') which is gradually depleted as dose increases. Another form of repair, which is not depleted ('P-repair'), increases the dose required to deliver an average of one lethal event per cell (dose 'D0'). Neither form of repair can unambiguously be linked with repair of defects in isolated DNA. An important initial lesion may well be disruption of the complex structural relationship between the DNA, nuclear membrane and associated proteins. One form of P-repair may be restoration of that structural relationship.

References

Nov 1, 1978·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I P Hesslewood
Jul 1, 1977·The British Journal of Radiology·T ALPER
Jan 15, 1989·Experientia·U Hagen
Jan 1, 1987·Progress in Biophysics and Molecular Biology·A George, W A Cramp
Dec 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K M PriseB D Michael
Nov 1, 1967·The British Journal of Radiology·T ALPER, J L Moore
Mar 1, 1972·Experimental Cell Research·R E Durand, R M Sutherland
Nov 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W A CrampK Erixon
Feb 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·W A CrampI Olsen
Jan 1, 1960·Annual Review of Nuclear Science·T ALPER
Jul 1, 1962·Physics in Medicine and Biology·E L POWERS
Dec 1, 1949·Proceedings of the National Academy of Sciences of the United States of America·K C Atwood, A Norman

Citations

Jan 15, 1989·Experientia·U Hagen
Jan 15, 1989·Experientia·A M Kellerer
Apr 7, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hakan DabakOzgur Isik
Jan 1, 1993·Environmental and Molecular Mutagenesis·J R Savage
Jan 21, 2004·The Journal of Biological Chemistry·Sandhya XavierAngelo Russo
Jun 1, 1997·International Journal of Radiation Biology·S Hornsey, J Denekamp

Related Concepts

Metazoa
Cell Survival
DNA, Double-Stranded
Genotoxic Stress
Base Excision Repair
Dose-Response Relationship, Radiation
Mathematics
Radiation Tolerance
Ionizing Radiation
Radiobiology

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