PMID: 7416577Mar 1, 1980Paper

The role of respiratory muscles in the hyperinflation of bronchial asthma

The American Review of Respiratory Disease
J G MartinL E Engel

Abstract

To examine the mechanism of hyperinflation in bronchial asthma we studied lung and chest wall mechanics in 7 asymptomatic patients in whom progressive bronchoconstriction was induced by doubling the amount of inhaled aerosolized histamine. An increase in pulmonary resistance (RL) from 2.5 +/- 0.3 cmH2O . 1-1 . s (mean, +/- 1 SE) to 12.3 +/- 0.9 cmH2 was associated with a linear increase in functional residual capacity (FRC) up to 74.7 +/- 1.7% of control total lung capacity (TLCc). The mean regression coefficient was 2.3% TLCc . cmH2O-1 . 1 . s-1. At each level of hyperinflation the most positive expiratory pleural pressures measured during spontaneous breathing were generally less than the predicted chest wall relaxation pressures, indicating persistent inspiratory muscle contraction throughout expiration. This was predominantly due to inspiratory intercostal and accessory muscle activity, because measurements of transdiaphragmatic pressure indicated complete diaphragmatic relaxation early in expiration. Recruitment of abdominal muscles during expiration, inferred from measurements of gastric pressure (Pg) and abdominal antero-posterior (A-P) diameter, was progressively more apparent with increasing bronchoconstriction. We con...Continue Reading

Citations

Feb 1, 1983·Chest·R L Hughes, R Davison
Nov 1, 1980·Chest·P T Macklem
Nov 1, 1981·Chest·J MartinL E Engel
Mar 1, 1996·Psychophysiology·F Boiten
Sep 18, 2010·Archivos de bronconeumología·Roberto Cano-De La CuerdaElena Muñoz-Hellín
Nov 27, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J Díaz LedoM Orozco Levi
Sep 1, 1987·The Journal of Allergy and Clinical Immunology·J M DrazenA Woolcock
Jun 1, 1983·The American Journal of Medicine·B E BrennerR R Simon
May 1, 1988·Australian and New Zealand Journal of Medicine·T V O'Donnell
Oct 1, 2005·Archivos de bronconeumología·A López-ViñaArea de Asma-SEPAR
Jan 1, 1982·Chest·J M Luce, B H Culver
Jan 1, 1992·The Australian Journal of Physiotherapy·B McCarren
Jul 13, 2016·Immunology and Allergy Clinics of North America·Jacqueline O'TooleDavid A Kaminsky
Aug 6, 2016·Respiratory Medicine·François VermeulenPierantonio Laveneziana
May 1, 1992·Behaviour Research and Therapy·R E CarrS M Hochron
Oct 6, 1997·Biological Psychiatry·G PernaL Bellodi
Feb 1, 1996·Intensive Care Medicine·C Roussos, S G Zakynthinos
Jun 1, 1995·Intensive Care Medicine·A RossiG Conti
Apr 1, 1994·Pediatric Pulmonology·H AstonM Silverman
Jan 19, 1999·Critical Care Clinics·Amal Jubran
Jun 7, 2018·The Clinical Respiratory Journal·Malay SarkarKushal Dogra
Sep 14, 2006·Applied Psychophysiology and Biofeedback·Thomas RitzBernhard Dahme
Nov 17, 2006·European Journal of Pediatrics·Erica A LopesCelso R F Carvalho
Jan 1, 1982·Lung·C Roussos
Mar 22, 2005·American Journal of Respiratory and Critical Care Medicine·Thomas BrackMartin J Tobin
Dec 1, 1994·European Journal of Clinical Investigation·M C CotéY Cormier
Jun 16, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Jason WeatheraldGilles Garcia
Apr 20, 2011·Medicine and Science in Sports and Exercise·Louise A TurnerMartin R Lindley
Jan 31, 2012·Expert Review of Respiratory Medicine·Joaquim GeaEsther Barreiro
Jun 10, 2009·The Journal of Physiological Sciences : JPS·Tetsuri KondoYuusuke Kondo
Jun 27, 2003·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Martin J Tobin
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M Younes
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·S G ZakynthinosC Roussos
Jan 1, 1982·Annals of the New York Academy of Sciences·C G PerssonE Svensjö
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A PurroC F Donner
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·M GoriniG Scano
Jan 5, 2000·American Journal of Respiratory and Critical Care Medicine·C G IrvinR J Martin
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·K J KillianP M O'Byrne
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Andrew P BinksRichard M Schwartzstein
Feb 14, 2006·Journal of Applied Physiology·Robert H BrownSolbert Permutt
Jan 27, 1983·The New England Journal of Medicine·B Camazine
Sep 23, 1982·The New England Journal of Medicine·C Roussos, P T Macklem
Oct 1, 1996·Journal of Applied Physiology·S YanP T Macklem
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·J A AlisonP T Bye
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·O BauerleM Younes
Apr 1, 1993·The American Review of Respiratory Disease·R D BallardD P White
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·M Diane LougheedDenis E O'Donnell
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·R C Chen, S Yan
Jul 1, 1990·The Annals of Otology, Rhinology, and Laryngology·J R HouckJ M McDonough
Jul 30, 1981·The New England Journal of Medicine·D F Rochester
Oct 6, 2007·Journal of Applied Physiology·Ronald Sorkness
Oct 29, 2000·Journal of Applied Physiology·I Homma, K E Hagbarth
Nov 17, 2009·American Journal of Respiratory and Critical Care Medicine·Athavudh DeesomchokDenis E O'Donnell
Dec 25, 2018·Respiratory Physiology & Neurobiology·Quentin BretonneauClaire de Bisschop

Related Concepts

Abdomen
Airway Resistance
Asthma
Lobar Bronchus Structure
Stenosis
Respiratory Diaphragm
Forced Expiratory Volume Function
Functional Residual Capacity
Structure of Intercostal Muscle
Lung Volume Measurements

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