The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.

Genetics Research International
Kyle A Nilson, David H Price

Abstract

HIV-1 usurps the RNA polymerase II elongation control machinery to regulate the expression of its genome during lytic and latent viral stages. After integration into the host genome, the HIV promoter within the long terminal repeat (LTR) is subject to potent downregulation in a postinitiation step of transcription. Once produced, the viral protein Tat commandeers the positive transcription elongation factor, P-TEFb, and brings it to the engaged RNA polymerase II (Pol II), leading to the production of viral proteins and genomic RNA. HIV can also enter a latent phase during which factors that regulate Pol II elongation may play a role in keeping the virus silent. HIV, the causative agent of AIDS, is a worldwide health concern. It is hoped that knowledge of the mechanisms regulating the expression of the HIV genome will lead to treatments and ultimately a cure.

References

Nov 16, 1990·Cell·R A MarciniakP A Sharp
May 26, 1995·The Journal of Biological Chemistry·N F Marshall, D H Price
Jan 1, 1994·Annual Review of Biochemistry·K A Jones, B M Peterlin
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·O FloresD Hazuda
Jun 3, 2000·Annual Review of Immunology·M Karin, Y Ben-Neriah
Jul 25, 2000·The Journal of Biological Chemistry·S H ChaoD H Price
Sep 13, 2001·The Journal of Biological Chemistry·D B RennerD H Price
Jul 23, 2002·Journal of Virology·Yael D KorinJerome A Zack
Aug 15, 2002·The Journal of Biological Chemistry·Scott R Eberhardy, Peggy J Farnham
Nov 21, 2002·Bioconjugate Chemistry·Venkitasamy KesavanTariq M Rana
Aug 29, 2003·Oncogene·Satoshi KanazawaB Matija Peterlin
Sep 26, 2003·Organic Letters·Michael A GelmanTariq M Rana
Feb 6, 2004·Genes and Immunity·F Pessler, R Q Cron
Apr 10, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Julian W Tang, Deenan Pillay
Jul 31, 2004·The Journal of Biological Chemistry·Samuel A WilliamsWarner C Greene
Nov 3, 2004·Trends in Molecular Medicine·Kara LassenRobert F Siliciano
Jul 5, 2005·Retrovirology·Alessandro FraldiLuigi Lania
Oct 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Murali PalangatRobert Landick
Jul 14, 2006·Medicinal Research Reviews·Miguel StevensJan Balzarini
Jul 25, 2006·Critical Reviews in Biochemistry and Molecular Biology·Mary C Thomas, Cheng-Ming Chiang
Jul 29, 2006·Expert Opinion on Pharmacotherapy·Zelalem TemesgenMary J Kasten
Aug 4, 2006·Molecular Cell·B Matija Peterlin, David H Price
Mar 8, 2007·Nucleic Acids Research·Matjaz BarboricQiang Zhou

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Citations

Jan 30, 2016·Trends in Biochemical Sciences·Jinwei Zhang, Robert Landick
May 3, 2016·Cell Systems·Husain A TalukdarJohan L M Björkegren
Apr 15, 2014·Cell Cycle·Jianyou GuTahir H Tahirov
May 20, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kaori AsamitsuTakashi Okamoto
Sep 26, 2012·Molecular and Cellular Biology·Iván D'OrsoAlan D Frankel

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Methods Mentioned

BETA
ChIP-Seq
immunoprecipitation
ChIP

Software Mentioned

HEXIM

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