PMID: 9450797Feb 5, 1998Paper

The role of rosetting in the multiplication of Plasmodium falciparum: rosette formation neither enhances nor targets parasite invasion into uninfected red cells

British Journal of Haematology
B CloughG Pasvoi

Abstract

The effect of rosette formation on the multiplication in vitro of Plasmodium falciparum was studied in order to establish whether rosetting acts as a major virulence factor in the pathogenesis of severe malaria by facilitating invasion of uninfected red cells. Invasion rates for rosetting (R+) and non-rosetting (R-) parasites selected from the same clone, PA1, of P. falciparum were similar over a range of starting parasite concentrations when assayed in both static cultures and conditions of shear stress comparable with microvascular flow. However, incubation of both R+ and R- parasites under simulated conditions of flow led to decreased invasion and fewer multiply-infected red cells as we have previously observed. Studies using fluorescently labelled red cells or reticulocytes demonstrated that rosetting did not alter the rates of invasion or target merozoites into the uninfected cells comprising a rosette. Preferential invasion of reticulocytes occurred regardless of rosetting or conditions of flow. Although the role of rosetting in the pathogenesis of malaria might relate to microvascular obstruction or perhaps the restriction of phagocytosis, our data suggest that rosetting does not play a role in the invasion or targeting ...Continue Reading

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Citations

Nov 19, 2010·Parasitology Research·Denis DelićFrank Wunderlich
Nov 13, 2002·Experimental Parasitology·Margaret J MackinnonJ Alexandra Rowe
Sep 10, 1999·International Journal for Parasitology·C NewboldT Fagan
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·J A SimpsonN J White
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Dec 17, 2002·Trends in Parasitology·Roger Jovani
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Margaret J Mackinnon, Andrew F Read
Sep 13, 2008·Annual Review of Microbiology·Fabienne Plattner, Dominique Soldati-Favre
Apr 1, 2010·Future Microbiology·Noelle Yvonne JemmelyPeter Rainer Preiser
May 5, 2009·Trends in Parasitology·Nicole Mideo
Jun 3, 2008·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O Mercereau-PuijalonI Vigan-Womas
Apr 9, 2004·Seminars in Hematology·Brian M CookeRoss L Coppel
Dec 21, 2005·Experimental Parasitology·Anne-Marie Deans, J Alexandra Rowe
Aug 10, 2005·Veterinary Parasitology·Brian M CookeRoss L Coppel
Jun 23, 2015·Molecular and Biochemical Parasitology·Jean-Philippe SemblatJ Alexandra Rowe
Aug 30, 2005·Anais Da Academia Brasileira De Ciências·Karin Kirchgatter, Hernando A Del Portillo
Jan 23, 2017·Trends in Parasitology·Xue Yan YamPeter R Preiser
Nov 2, 2017·Molecular BioSystems·Xue Yan Yam, Peter R Preiser
Jul 19, 2019·Frontiers in Immunology·Wenn-Chyau LeeLaurent Rénia
Jun 1, 1999·Evolution; International Journal of Organic Evolution·Margaret J Mackinnon, Andrew F Read
Jun 14, 2021·Trends in Parasitology·Bénédicte GnangnonCaroline O Buckee

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