The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jayne F Martin CarliRudolph L Leibel

Abstract

Genetic variants within the FTO (α-ketoglutarate-dependent dioxygenase) gene have been strongly associated with a modest increase in adiposity as a result of increased food intake. These risk alleles are associated with decreased expression of both FTO and neighboring RPGRIP1L (retinitis pigmentosa GTPase regulator-interacting protein 1 like). RPGRIP1L encodes a protein that is critical to the function of the primary cilium, which conveys extracellular information to the cell. Rpgrip1l+/- mice exhibit increased adiposity, in part, as a result of hyperphagia. Here, we describe the effects of Rpgrip1l in adipocytes that may contribute to the adiposity phenotype observed in these animals and possibly in humans who segregate for FTO risk alleles. Loss of Rpgrip1l in 3T3-L1 preadipocytes increased the number of cells that are capable of differentiating into mature adipocytes. Knockout of Rpgrip1l in mature adipocytes using Adipoq-Cre did not increase adiposity in mice that were fed chow or a high-fat diet. We also did not observe any effects of Rpgrip1l knockdown in mature 3T3-L1 adipocytes. Thus, to the extent that Rpgrip1l affects cell-autonomous adipose tissue function, it may do so as a result of the effects conveyed in preadipo...Continue Reading

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Citations

Feb 8, 2019·JCI Insight·Liheng WangGeorge Stratigopoulos
Sep 19, 2019·Physiological Genomics·Richard GillRudolph L Leibel
May 24, 2019·Obesity·Lisa M RanzenhoferMichael Rosenbaum
Nov 4, 2020·Biomolecules·Jie L Tian, Farzad Islami Gomeshtapeh
Feb 27, 2021·American Journal of Human Genetics·Theodore George DrivasMarylyn DeRiggi Ritchie

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