The role of salvage surgery with interstitial brachytherapy for the Management of Regionally Recurrent Head and Neck Cancers.

Cancers of the Head & Neck
Nayel KhanMichael E Kupferman

Abstract

The optimal treatment for regional lymphatic recurrences from head and neck cancer has not been fully established. In order to explore the therapeutic benefit of surgical resection and adjuvant brachytherapy, the authors reviewed their experience utilizing interstitial brachytherapy (IBT) at the M. D. Anderson Cancer Center. A retrospective chart review of the 51 patients who received salvage surgical resection of lymphatic recurrences and adjuvant IBT between 1993 and 2012 at the M. D. Anderson Cancer Center was undertaken. All patients underwent neck dissection with complete resection and intraoperative placement of afterloading brachytherapy catheters. Soft tissue reconstruction was performed as necessary. The technical aspects of IBT were reviewed, and the overall and disease free survival rates and the recurrence rates were determined. All patients had received external beam radiation (EBRT) as part of their initial treatment to a median dose of 66 Gy; 40 and 68% of the patients also had a neck dissection or chemotherapy, respectively. The cumulative regional recurrence probability is 28 and 38% at 5 years and 10 years. All of the patients underwent salvage neck dissection and IBT, with 81% also undergoing soft tissue reco...Continue Reading

References

Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·A PuthawalaV Nixon
Dec 1, 2001·International Journal of Radiation Oncology, Biology, Physics·M A BolletP Bey
Jan 3, 2006·Head & Neck·Ivan Marcelo Gonçalves AgraLuiz Paulo Kowalski
Jul 28, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christopher NuttingKevin Harrington
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 9, 2013·Head & Neck·Allen S HoLuc G T Morris
Apr 16, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mingsi LiJoseph Scharpf

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Methods Mentioned

BETA
surgical resections
dissection
biopsies
surgical resection
surgical
dissections

Software Mentioned

R R Foundation for Statistical Computing
SAS

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