The role of secretin in the cerebellum

The Cerebellum
Wing-Ho YungJian-Jun Wang

Abstract

There is increasing interest in the role played by secretin in the central nervous system. Recent evidence suggests that this peptide is widely expressed in the brain but some areas, notably the cerebellum, show a prominent expression of the peptide and its specific receptor. In this article we summarize our current understanding of the expression pattern and action of secretin in the cerebellum. We discuss the findings supporting the endogenous release of this peptide from Purkinje neurons and its role as a retrograde messenger modulating GABAergic synaptic transmission via multiple mechanisms. In addition, we would like to propose other possible, but still to be confirmed, functions of secretin in the cerebellum..

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Citations

Nov 21, 2007·Cellular and Molecular Neurobiology·Jing-Ning Zhu, Jian-Jun Wang
Jun 29, 2010·Journal of Molecular Neuroscience : MN·Andrea HeinzlmannKatalin Köves
Jul 8, 2010·Journal of Molecular Neuroscience : MN·Katalin KövesGyula Szabó
Oct 16, 2012·Journal of Molecular Neuroscience : MN·Zsuzsanna E TóthKatalin Köves
May 27, 2010·Journal of Endocrinological Investigation·D H St-Pierre, F Broglio
Jan 5, 2011·Archives of Medical Research·Juan José MandokiFausto Alejandro Jiménez-Orozco
Sep 26, 2006·Journal of Neuroscience Research·Jing-Ning ZhuJian-Jun Wang
Mar 11, 2011·Annals of the New York Academy of Sciences·Yuan YuanBilly K C Chow
Jul 5, 2005·Biological Psychiatry·Karyn M MyersMichael Davis
Jun 9, 2018·Journal of Molecular Neuroscience : MN·Ruanna WangLi Zhang

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