The role of senescence of bone marrow cells in acute kidney injury

Kidney Research and Clinical Practice
Junyong LeeMyung-Gyu Kim

Abstract

The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes. This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. Female 7-week-old C57BL/6 mice were irradiated and treated with BM cells from either 48-week-old or 8-week-old male mice. Ischemia-reperfusion injury (IRI) was induced, and their functional deterioration, histological tubular damage, and inflammatory responses were compared. For the in vitro study, lipopolysaccharide (LPS)-stimulated cytokine production by BM cells from old and young mice were examined. At 24 hours after IRI, there was no significant difference in the number of circulating immune cells between the mice transplanted with old or young BM cells. However, the mice with old BM cells showed less functional deterioration and histological tubular injury than those with young BM cells. Moreover, macrophage infiltration and renal cytokine interleukin (IL)-12 levels were lower in the mice with old BM cells at 24 hours post-IRI. Consistently, the in vitro study showed that LPS-induced pr...Continue Reading

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Citations

Mar 23, 2019·Kidney Research and Clinical Practice·Hideo Yasuda
Dec 27, 2019·PloS One·Islam Md ImtiazulHyo-Wook Gil
Apr 3, 2020·Journal of Cellular and Molecular Medicine·Jung Nam AnJung Pyo Lee
Apr 3, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yu Jin JungWon Kim
Dec 6, 2019·Scientific Reports·Myung-Gyu KimSang-Kyung Jo

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Methods Mentioned

BETA
electrophoresis
PCR
FACS

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