The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
C N Mowa, R E Papka

Abstract

Central nervous system nuclei and circuits, such as the medial preoptic, ventromedial and paraventricular nuclei of the hypothalamus, play important roles in reproduction and parturition, and are influenced by estrogen. Peripheral autonomic and sensory neurons also play important roles in pregnancy and parturition. Moreover, the steroid hormone estrogen acts directly, not only on the reproductive tract organs (uterus and cervix), but also on the central and peripheral nerves by regulating expression of various neuronal genes. The peripheral primary afferent neurons innervating the uterine cervix relay mechanical and biochemical sensory information induced by local cervical events and by passage of fetuses, to the spinal cord and supraspinal centers. Consequently, the birth process in mammals is influenced by the combined action of neurons and hormones. Peripheral sensory stimuli, induced physiologically by fetal expulsion or mechanically by vaginocervical stimulation, alter behavior, as well as autonomic and neuroendocrine systems. Recent evidence indicates that primary afferent neurons innervating the cervix, in addition to their sensory effects, likely exert local "efferent" actions on the ripening cervix near term. These eff...Continue Reading

References

Jul 1, 1991·American Journal of Obstetrics and Gynecology·T TaniguchiO Tanizawa
Jan 1, 1990·Anatomy and Embryology·H W BurdenC A Hodson
Apr 1, 1991·Trends in Pharmacological Sciences·B S McEwen
Jun 1, 1990·Baillière's Clinical Endocrinology and Metabolism·P J Steer
Jan 1, 1988·Journal of Neurophysiology·K J BerkleyY Sato
Mar 25, 1987·Nucleic Acids Research·S KoikeM Muramatsu
Jan 1, 1988·General Pharmacology·C A Maggi, A Meli
Feb 18, 1983·Science·D W Pfaff, B S McEwen
Dec 1, 1984·The Anatomical Record·H W BurdenI E Lawrence
Jan 1, 1993·American Journal of Obstetrics and Gynecology·N MatsuzakiO Tanizawa
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
May 1, 1997·Cell and Tissue Research·E B HaaseL P Schramm
May 22, 1998·Journal of Perinatal Medicine·K J ArntzenR Austgulen
Jun 9, 1998·Physiology & Behavior·M Martínez-GómezR Hudson
Jun 24, 1998·Biochemical and Biophysical Research Communications·J T MooreT M Willson
Dec 4, 1998·Archives of Gynecology and Obstetrics·W Chaim, M Mazor
Feb 5, 1999·Cell and Tissue Research·J J CollinsR E Papka
Aug 17, 1999·Brain Research·E F RissmanT C Foster
Oct 7, 2000·Obstetrical & Gynecological Survey· Challis JRG

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Citations

Dec 18, 2008·Reproductive Biology and Endocrinology : RB&E·Chishimba N MowaGuichuan Hou
May 17, 2005·Journal of Cellular Physiology·Maria De Falco, Antonio De Luca
Mar 21, 2008·Matrix Biology : Journal of the International Society for Matrix Biology·Monika RuscheinskyMala Mahendroo
Oct 14, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Antonio MalvasiStefano Bettocchi
Aug 4, 2006·Clinical Obstetrics and Gynecology·Holger MaulRobert E Garfield
May 11, 2012·PloS One·Eduardo Martínez-MartínezGabriel Gutiérrez-Ospina
Nov 24, 2004·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C N MowaR Papka
Dec 6, 2005·Journal of the Society for Gynecologic Investigation·Laura S KirbySteven M Yellon
Jul 21, 2007·Endocrine Reviews·Rainer H Straub
Feb 7, 2013·The Journal of Endocrinology·Siobhan M DonnellyChishimba Nathan Mowa
May 20, 2005·Cell and Tissue Research·Raymond E PapkaMegan Storey-Workley
May 24, 2020·Animals : an Open Access Journal From MDPI·Barbara Jana, Jarosław Całka
Jan 23, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jonathan W BoydSteven M Yellon
Feb 1, 2020·Current Pharmaceutical Design·Ioannis P KosmasAndrea Tinelli

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