The role of sentinel lymph node biopsy in select sarcoma patients: a meta-analysis

American Journal of Surgery
Sharee WrightE Ramsay Camp

Abstract

Sentinel lymph node (SLN) biopsy is a staging technique for occult lymph node disease. SLN biopsy has been applied to select patients with sarcoma, although the clinical utility remains uncertain. A PubMed/MEDLINE literature search was performed, and SLN biopsy outcomes were analyzed using a Bayesian meta-analytic approach to obtain point and interval estimates of rates of interest. Sixteen studies involving SLN biopsy in patients with sarcoma were identified. Of 114 patients reported, 14 patients had positive SLNs (crude estimate, 12%; meta-analysis estimate, 17%). The meta-analysis false-negative rate was 29% (95% credible interval, 5%-59%). Recurrence and death rates in the SLN-positive group were higher than in the SLN-negative group. This investigation highlights the current role of SLN biopsy in select patients with sarcoma for tumor staging. Questions regarding the high false-negative rate and management of micrometastatic lymphatic disease in patients with sarcoma still exist.

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Citations

Feb 2, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D AndreouP-U Tunn
Jun 5, 2013·International Journal of Clinical Oncology·Yoshihiro NishidaNaoki Ishiguro
Jun 29, 2013·American Journal of Surgery·David JohannesmeyerE Ramsay Camp
Jun 10, 2014·Journal of Surgical Oncology·Karen L ShermanKarl Y Bilimoria
Oct 28, 2016·Annals of Surgical Oncology·Brett L EckerGiorgos C Karakousis
Aug 25, 2019·Skeletal Radiology·Jeffrey RosenthalAdam Daniel Singer
May 22, 2018·American Journal of Clinical Oncology·Deanna Wan Jie NgMelissa Ching Ching Teo
Jan 5, 2021·Annals of Surgical Oncology·Nicholas M SiegelAdam S Levin
Jun 18, 2016·Retinal Cases & Brief Reports·Nikisha Q RichardsS Tonya Stefko
Sep 16, 2020·The Journal of the American Academy of Orthopaedic Surgeons·Jonathan LansSantiago A Lozano Calderon
Mar 23, 2021·Journal of Surgical Oncology·Ugwuji N MaduekwePhilip M Spanheimer
Jun 1, 2021·Annals of Surgical Oncology·Bernadette JeremiasseCecilia E J Terwisscha van Scheltinga
Jul 15, 2020·Current Medical Imaging·Shinji TsukamotoCostantino Errani

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