The role of serotonin in cardiovascular diseases and their treatment

Cardiovascular Drugs and Therapy
P A van ZwietenP van Brummelen

Abstract

Serotonin (5HT), discovered in the 1950s, has been the subject of renewed interest for several years, in particular due to the subdivision of 5HT receptors into various types. Concomitantly, several more or less selective agonists and antagonists for these various receptor subtypes have been developed. Although the physiologic relevance of 5HT remains largely unknown, its role in certain pathologic processes is widely accepted. Certain symptoms of the carcinoid syndrome, thromboembolic processes at the level of the microcirculation, and possibly also coronary spasm and peripheral vascular disease are likely to be associated, at least in part, with endogenous 5HT and serotonergic mechanisms. However, a primary and causative role for such mechanisms in essential hypertension seems unlikely. The blockade of peripheral 5HT2 receptors with drugs may offer advantages, in particular in those disorders where an interaction between predamaged blood vessels and platelets is involved. Such a therapeutic approach seems to be a more generally applicable principle than the lowering of blood pressure as such, which appears not to be a general phenomenon provoked by 5HT2-receptor blockade.

References

Jul 29, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luca CarnevaliEugene Nalivaiko
Feb 24, 2004·Cardiovascular Drug Reviews·Harjot K SainiN S Dhalla

Citations

Jan 1, 1990·Cardiovascular Drugs and Therapy·N FetkovskaF R Bühler
Jan 1, 1990·British Journal of Clinical Pharmacology·P A van ZwietenP van Brummelen
Jan 1, 1987·Journal of Cardiovascular Pharmacology·M Göthert, E Schlicker
Jan 1, 1988·Journal of Cardiovascular Pharmacology·F De ClerckD de Chaffoy de Courcelles
Aug 15, 1989·The American Journal of Cardiology·P A van Zwieten
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·G J BlauwP A van Zwieten
Aug 21, 1982·Lancet·J de Roose, J Symoens
Jan 1, 1984·Journal of Cardiovascular Pharmacology·P M VanhoutteJ M Van Nueten
Jan 1, 1983·Canadian Anaesthetists' Society Journal·P W LebowitzN Sunder
Jul 1, 1954·Physiological Reviews·I H PAGE

Related Concepts

Carcinoid Tumor
Receptors, Tryptamine
Essential Hypertension
Cardiovascular Diseases
Antihypertensive Agents
Peripheral Vascular Diseases
Metazoa
Spasm
Hydroxytryptamine

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.