The role of serum CA-125 levels and CA-125 tissue expression positivity in the prediction of the recurrence of stage III and IV epithelial ovarian tumors (CA-125 levels and tissue CA-125 in ovarian tumors)

Archives of Gynecology and Obstetrics
Fatih GundogduAli Yavuzcan

Abstract

The present study investigates the effects of serum CA-125 level and CA-125 tissue positivity on first-year recurrences in patients with stage III/IV epithelial ovarian tumors. Of the 101 patients with EOC who had undergone systematic pelvic/para-aortic lymphadenectomy between January 2003 and December 2007 recurrence did not develop in patients with stage I/II EOC. Fifty-five patients with FIGO stage III/IV EOC were evaluated in terms of serum CA-125 level and CA-125 tissue positivity. Preoperative CA-125 levels, under 35 IU/l were considered normal. To determine the expression of CA-125 immunohistochemically, stainings exceeding 10% were considered as positive. The relationship between CA-125 values and recurrence was significant in stage III/IV patients (p = 0.041/p = 0.006). The relationship between CA-125 values and recurrence was significant in the patients with serous tumor, endometrioid tumor, clear cell tumor, and undifferentiated tumor (p = 0.034/p = 0.044/p = 0.039/p = 0.043 respectively, p < 0.05). It was insignificant in mucinous tumor (p = 0.667). The relationship between CA-125 tissue expression positivity and recurrence development was significant in stage III/IV patients (p = 0.041/p = 0.029). It was significan...Continue Reading

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Citations

Nov 1, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shu-Ming HeShu-Feng Zhou
Nov 8, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G CollocaI Governato
Jan 31, 2012·American Journal of Obstetrics and Gynecology·Richard G MooreRobert C Bast

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