The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study

Diabetic Medicine : a Journal of the British Diabetic Association
C S HansenM E Jørgensen

Abstract

Cardiovascular autonomic neuropathy and diabetic peripheral neuropathy are common diabetic complications and independent predictors of cardiovascular disease. The glucose metabolite methylglyoxal has been suggested to play a causal role in the pathogeneses of diabetic peripheral neuropathy and possibly diabetic cardiovascular autonomic neuropathy. The aim of this study was to investigate the cross-sectional association between serum methylglyoxal and diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in a subset of patients in the ADDITION-Denmark study with short-term screen-detected Type 2 diabetes (duration ~ 5.8 years). The patients were well controlled with regard to HbA(1c), lipids and blood pressure. Cardiovascular autonomic neuropathy was assessed by measures of resting heart rate variability and cardiovascular autonomic reflex tests. Diabetic peripheral neuropathy was assessed by vibration detection threshold (n = 319), 10 g monofilament (n = 543) and the Michigan Neuropathy Screening Instrument questionnaire (n = 966). Painful diabetic neuropathy was assessed using the Brief Pain Inventory short form (n = 882). No associations between methylglyoxal and cardiovascular autonomic reflex tests or any m...Continue Reading

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Citations

Sep 18, 2016·Journal of Diabetes and Its Complications·Christian S HansenJesper Fleischer
Sep 17, 2016·Medicinal Research Reviews·Paulo MatafomeRaquel Seiça
Oct 4, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·C S HansenM E Jørgensen
Dec 30, 2016·Diabetes/metabolism Research and Reviews·Vincenza Spallone
May 6, 2017·International Journal of Molecular Sciences·Sebastian BringsPeter P Nawroth
Nov 22, 2018·Diabetes Technology & Therapeutics·Marie Mathilde Bjerg ChristensenChristian Stevns Hansen
Sep 27, 2018·Endocrine Reviews·Gidon J BönhofDan Ziegler
Jan 31, 2019·The Cochrane Database of Systematic Reviews·Lasse T KrogsbøllPeter C Gøtzsche
Jun 15, 2019·Nature Reviews. Disease Primers·Eva L FeldmanVijay Viswanathan
Apr 30, 2019·Frontiers in Endocrinology·Christian Stevns HansenThomas Fremming Dejgaard
Oct 20, 2020·Frontiers in Endocrinology·Marie Mathilde Bjerg ChristensenChristian Stevns Hansen
Nov 10, 2020·Molecular Metabolism·Alexander StromUNKNOWN GDS Group
Mar 7, 2021·International Journal of Molecular Sciences·Yoshikai FujitaAkihiro Nakamura
May 30, 2021·Nature Reviews. Endocrinology·Gordon SloanSolomon Tesfaye
Sep 3, 2021·International Journal of Clinical Practice·Rumyana DimovaTsvetalina Tankova

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