The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis

Viruses
Ruth McBride, Burtram C Fielding

Abstract

A respiratory disease caused by a novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), was first reported in China in late 2002. The subsequent efficient human-to-human transmission of this virus eventually affected more than 30 countries worldwide, resulting in a mortality rate of ~10% of infected individuals. The spread of the virus was ultimately controlled by isolation of infected individuals and there has been no infections reported since April 2004. However, the natural reservoir of the virus was never identified and it is not known if this virus will re-emerge and, therefore, research on this virus continues. The SARS-CoV genome is about 30 kb in length and is predicted to contain 14 functional open reading frames (ORFs). The genome encodes for proteins that are homologous to known coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major structural proteins: nucleocapsid (N), spike (S), membrane (M) and envelope (E). SARS-CoV also encodes for eight unique proteins, called accessory proteins, with no known homologues. This review will summarize the current knowledge on SARS-CoV accessory proteins and will include: (i) expression and processing; (ii) t...Continue Reading

References

Dec 1, 1990·Trends in Biochemical Sciences·H R Pelham
Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D Hamre, J J Procknow
Dec 5, 1998·The Journal of Biological Chemistry·P AskjaerJ Kjems
Jan 5, 2002·Journal of Virology·Kristopher M CurtisRalph S Baric
Jan 5, 2002·Advances in Experimental Medicine and Biology·E OntiverosS Perlman
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wulf SienelBernward Passlick
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 6, 2003·Science·Marco A MarraRachel L Roper
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Aug 2, 2003·The New England Journal of Medicine·Gang LiAnlong Xu
Aug 15, 2003·The Journal of General Virology·Volker ThielJohn Ziebuhr
Sep 16, 2003·FEBS Letters·Marie L KellyLawrence H Pinto
Jun 5, 1965·British Medical Journal·D A TYRRELL, M L BYNOE
Dec 4, 2003·Biochemical and Biophysical Research Communications·Xiaodong XiaoDimiter S Dimitrov
Dec 17, 2003·Cell·Dimiter S Dimitrov
Jan 31, 2004·Science·UNKNOWN Chinese SARS Molecular Epidemiology Consortium
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tai-Nin ChauChing-Lung Lai
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bojian ZhengHsiang-Fu Kung
Feb 18, 2005·Emerging Infectious Diseases·Rossa W K ChiuY M Dennis Lo
Mar 15, 2005·Virus Research·Xiaoling YuanYuwen Cong
Mar 23, 2005·Biochemical and Biophysical Research Communications·Shuo ShenYee-Joo Tan

❮ Previous
Next ❯

Citations

Nov 5, 2013·Antiviral Research·Jan Felix DrexlerChristian Drosten
Aug 7, 2013·Science China. Life Sciences·HeYuan Geng, WenJie Tan
Sep 21, 2015·Apoptosis : an International Journal on Programmed Cell Death·Ahmad Naqib ShuidAbdul Rahman Omar
Feb 11, 2015·Virus Research·Anne-Laure Pham-Hung d'Alexandry d'OrengianiSophie Le Poder
May 20, 2014·The Veterinary Journal·Niels C Pedersen
Aug 6, 2014·Virus Research·Marta L DeDiegoLuis Enjuanes
May 11, 2012·Current Opinion in Virology·Allison L Totura, Ralph S Baric
Apr 17, 2014·Reviews in Medical Virology·Yingying Cong, Xiaofeng Ren
Apr 29, 2014·Expert Review of Vaccines·Naru ZhangLanying Du
Apr 17, 2020·Journal of Biomolecular Structure & Dynamics·Maryam EnayatkhaniKhadijeh Ahmadi
Jul 25, 2016·Diseases·Yvonne Xinyi LimDing Xiang Liu
Jul 28, 2020·Cellular and Molecular Life Sciences : CMLS·Rajanish GiriVladimir N Uversky
May 14, 2020·Virusdisease·Saraj BahadurMuhammad Shuaib
Aug 6, 2020·Frontiers in Physiology·José Díaz
Aug 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chong-Shan ShiJohn H Kehrl
Aug 29, 2020·Virology Journal·Christian Jean MichelJulie Dawn Thompson
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Dec 29, 2020·Computational and Structural Biotechnology Journal·Christos A Ouzounis
Aug 25, 2020·Heliyon·I Made ArtikaAgeng Wiyatno
Feb 3, 2021·International Journal of Molecular Sciences·Nicholas A Wong, Milton H Saier
Feb 2, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·I Made ArtikaChairin Nisa Ma'roef
Mar 6, 2021·Frontiers in Genetics·Sreyashi MajumdarSudipto Saha
Nov 7, 2020·Frontiers in Immunology·Conor McClenaghanColin G Nichols
Mar 10, 2021·Biochemical and Biophysical Research Communications·Luca Zinzula
Oct 1, 2020·Cell Reports Medicine·Colin R ZamecnikMichael R Wilson
Apr 13, 2021·Journal of Pharmaceutical Analysis·Donata Pluskota-KarwatkaJan Barciszewski
May 13, 2021·ACS Biomaterials Science & Engineering·Elham BidramPooyan Makvandi
Jun 18, 2021·BMC Infectious Diseases·Elijah Nicholas MulabbiDenis K Byarugaba
Jun 30, 2021·Cytokine & Growth Factor Reviews·Ni ZhaoLi-Li Xu

❮ Previous
Next ❯

Methods Mentioned

BETA
co-immunoprecipitation
biopsies
transfection
ELISA
nuclear translocation
chip
fluorescence microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.