The role of severe acute respiratory syndrome (SARS)-coronavirus accessory proteins in virus pathogenesis

Ruth McBride, Burtram C Fielding


A respiratory disease caused by a novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), was first reported in China in late 2002. The subsequent efficient human-to-human transmission of this virus eventually affected more than 30 countries worldwide, resulting in a mortality rate of ~10% of infected individuals. The spread of the virus was ultimately controlled by isolation of infected individuals and there has been no infections reported since April 2004. However, the natural reservoir of the virus was never identified and it is not known if this virus will re-emerge and, therefore, research on this virus continues. The SARS-CoV genome is about 30 kb in length and is predicted to contain 14 functional open reading frames (ORFs). The genome encodes for proteins that are homologous to known coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major structural proteins: nucleocapsid (N), spike (S), membrane (M) and envelope (E). SARS-CoV also encodes for eight unique proteins, called accessory proteins, with no known homologues. This review will summarize the current knowledge on SARS-CoV accessory proteins and will include: (i) expression and processing; (ii) t...Continue Reading


Dec 1, 1990·Trends in Biochemical Sciences·H R Pelham
Jan 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·D Hamre, J J Procknow
Dec 5, 1998·The Journal of Biological Chemistry·P AskjaerJ Kjems
Jan 5, 2002·Journal of Virology·Kristopher M CurtisRalph S Baric
Jan 5, 2002·Advances in Experimental Medicine and Biology·E OntiverosS Perlman
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 16, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wulf SienelBernward Passlick
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 6, 2003·Science·Marco A MarraRachel L Roper
May 16, 2003·Nature·Ron A M FouchierAlbert D M E Osterhaus
Aug 2, 2003·The New England Journal of Medicine·Gang LiAnlong Xu
Aug 15, 2003·The Journal of General Virology·Volker ThielJohn Ziebuhr
Sep 16, 2003·FEBS Letters·Marie L KellyLawrence H Pinto
Jun 5, 1965·British Medical Journal·D A TYRRELL, M L BYNOE
Dec 4, 2003·Biochemical and Biophysical Research Communications·Xiaodong XiaoDimiter S Dimitrov
Dec 17, 2003·Cell·Dimiter S Dimitrov
Jan 31, 2004·Science·UNKNOWN Chinese SARS Molecular Epidemiology Consortium
Feb 10, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tai-Nin ChauChing-Lung Lai
Mar 23, 2004·Nature Medicine·Lia van der HoekBen Berkhout
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bojian ZhengHsiang-Fu Kung
Feb 18, 2005·Emerging Infectious Diseases·Rossa W K ChiuY M Dennis Lo
Mar 15, 2005·Virus Research·Xiaoling YuanYuwen Cong
Mar 23, 2005·Biochemical and Biophysical Research Communications·Shuo ShenYee-Joo Tan

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Methods Mentioned

nuclear translocation
fluorescence microscopy

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