The role of sex hormone-binding globulin (SHBG), testosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men

Acta Diabetologica
Prabin GyawaliGary A Wittert

Abstract

Contrasting findings exist regarding the association between circulating sex hormone-binding globulin (SHBG) and testosterone levels and type 2 diabetes (T2D) in men. We examined prospective associations of SHBG and sex steroids with incident T2D in a cohort of community-dwelling men. Participants were from a cohort study of community-dwelling (n = 2563), middle-aged to elderly men (35-80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study). The current study included men who were followed for 5 years and with complete SHBG and sex steroid levels (total testosterone (TT), dihydrotestosterone (DHT) and oestradiol (E2)), but without T2D at baseline (n = 1597). T2D was identified by either self-report, fasting glucose (≥ 7.0 mmol/L), HbA1c (≥ 6.5%/48.0 mmol/mol), and/or prescriptions for diabetes medications. Logistic binomial regression was used to assess associations between SHBG, sex steroids and incident T2D, adjusting for confounders including age, smoking status, physical activity, adiposity, glucose, triglycerides, symptomatic depression, SHBG and sex steroid levels. During an average follow-up of 4.95 years, 14.5% (n = 232) of men developed new T2D. Multi-adjusted ...Continue Reading

References

Jan 1, 1974·Clinical Endocrinology·D C Anderson
Jul 1, 1993·The Journal of Clinical Endocrinology and Metabolism·S M HaffnerM P Stern
Jan 1, 1996·Hormone Research·G L Hammond, W P Bocchinfuso
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·W RosnerN A Romas
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Feb 5, 2000·Diabetes Research and Clinical Practice·M OkuboM Yamakido
Sep 23, 2000·Calcified Tissue International·R B Mazess, H S Barden
Oct 16, 2002·The Journal of Endocrinology·S M KahnW Rosner
Mar 16, 2006·JAMA : the Journal of the American Medical Association·Eric L DingSimin Liu
Jun 28, 2007·BMC Public Health·Sean A MartinUNKNOWN Members of the Florey Adelaide Male Ageing Study (FAMAS)
Aug 7, 2009·The New England Journal of Medicine·Eric L DingSimin Liu
Jan 29, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kishore M LakshmanAndre B Araujo
Oct 26, 2010·International Journal of Andrology·G CoronaM Maggi
Nov 3, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sabine SchipfHenri Wallaschofski
May 27, 2011·Biology of Reproduction·Geoffrey L Hammond
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Mathis Grossmann
Jun 18, 2011·European Journal of Clinical Investigation·Federico SoriguerGemma Rojo-Martínez
Apr 26, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Geoffrey L HammondMarc Simard
Nov 6, 2012·Clinical Endocrinology·Ian R WallaceSteven J Hunter
Mar 6, 2013·Biochemia Medica·Serap CuhadarAhmet Dirican
Jun 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Zumin ShiGary A Wittert
Jun 21, 2013·International Journal of Epidemiology·Janet F GrantGary A Wittert
Jun 26, 2013·Nature Reviews. Endocrinology·Preethi M RaoT Hugh Jones
Jun 4, 2014·Geriatrics & Gerontology International·Marika SalminenKerttu Irjala
Jun 6, 2015·Trends in Endocrinology and Metabolism : TEM·Rafael SimóDavid M Selva
Jul 23, 2015·The Journal of Clinical Endocrinology and Metabolism·K J MatherUNKNOWN Diabetes Prevention Program
Jun 11, 2016·The Journal of Clinical Endocrinology and Metabolism·Stine A HolmboeAnna-Maria Andersson
Oct 13, 2016·The Journal of Clinical Endocrinology and Metabolism·Katherine E JoyceKenneth J Mukamal

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Citations

Dec 7, 2018·Endocrine Connections·Daiki KobayashiHiroshi Noto
Dec 12, 2018·Endocrine Connections·Alessandra Gambineri, Carla Pelusi
Dec 29, 2018·Endocrine Connections·Kristin OttarsdottirBledar Daka
Sep 11, 2019·Andrology·M GrossmannA S Cheung
Jun 6, 2020·Frontiers in Endocrinology·Genaro BarrientosManuel Estrada
Aug 8, 2019·The Journal of Clinical Endocrinology and Metabolism·Prabin GyawaliGary A Wittert
Nov 2, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mehdi BasakiSaeedeh Saeb
Jul 23, 2021·Cardiovascular Research·Antonio CittadiniAndrea Salzano
Feb 3, 2022·European Geriatric Medicine·Xuchao PengJirong Yue

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